Screening Models for Early Detection of Late-onset Preeclampsia With Various Markers in Low-risk Pregnancy Populations
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 262
- 主要终点
- identification of patients at risk for late-onset preeclampsia with sFlt-1/PlGF ratio
研究概览
简要总结
For the prediction of late-onset preeclampsia (PE) in low risk women, the investigators established a cut-off value for sFlt-1/PlGF ratio and evaluated the combination models of Elecys, second trimester uterine artery (UtA) doppler, and fetoplacental proteins for Down syndrome screening.
详细描述
A prospective study was carried on in Cha hospital. Serum samples for Down syndrome screening were assayed to estimate pregnancy-associated plasma protein-A (PAPP-A), alpha-fetoprotein , unconjugated estriol, human chorionic gonadotrophin , and inhibin-A. Women screened for Down syndrome were offered UtA Doppler at 20-24 weeks of gestation and then collected serial serum samples for sFlt-1/PlGF ratio at two time points (24-27 and 34-37 weeks' gestation).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 39 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women considered as a potential participant in this research were patients regularly visited at the prenatal care of Cha hospital in Seoul, Korea
排除标准
- •early onset and cases not to measure the sFlt/PlGF ratio and other markers
- •twin pregnancy
- •Chronic hypertension
- •prior history of preeclampsia
- •pregestational diabetes mellitus
- •gestational diabetes mellitus
- •patients delivered before 35 weeks of gestation
- •preeclamptic patients with onset before 35 weeks of gestation
- •patients with body mass index 25kg/m2 or greater
- •maternal age 40 years older
结局指标
主要结局
identification of patients at risk for late-onset preeclampsia with sFlt-1/PlGF ratio
时间窗: at delivery
次要结局
- identification of patients at risk for late-onset preeclampsia with combined biochemical markers(at delivery)