Screening for Preeclampsia With Various Markers in Low-risk Pregnancy Populations
Completed
- Conditions
- Preeclampsia
- Registration Number
- NCT01649128
- Lead Sponsor
- CHA University
- Brief Summary
For the prediction of late-onset preeclampsia (PE) in low risk women, the investigators established a cut-off value for sFlt-1/PlGF ratio and evaluated the combination models of Elecys, second trimester uterine artery (UtA) doppler, and fetoplacental proteins for Down syndrome screening.
- Detailed Description
A prospective study was carried on in Cha hospital. Serum samples for Down syndrome screening were assayed to estimate pregnancy-associated plasma protein-A (PAPP-A), alpha-fetoprotein , unconjugated estriol, human chorionic gonadotrophin , and inhibin-A. Women screened for Down syndrome were offered UtA Doppler at 20-24 weeks of gestation and then collected serial serum samples for sFlt-1/PlGF ratio at two time points (24-27 and 34-37 weeks' gestation).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 262
Inclusion Criteria
- Women considered as a potential participant in this research were patients regularly visited at the prenatal care of Cha hospital in Seoul, Korea
Exclusion Criteria
- early onset and cases not to measure the sFlt/PlGF ratio and other markers
- twin pregnancy
- Chronic hypertension
- prior history of preeclampsia
- pregestational diabetes mellitus
- gestational diabetes mellitus
- patients delivered before 35 weeks of gestation
- preeclamptic patients with onset before 35 weeks of gestation
- patients with body mass index 25kg/m2 or greater
- maternal age 40 years older
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method identification of patients at risk for late-onset preeclampsia with sFlt-1/PlGF ratio at delivery
- Secondary Outcome Measures
Name Time Method identification of patients at risk for late-onset preeclampsia with combined biochemical markers at delivery