Application of integrated traditional Chinese and Western medicine care in senile dementia patients

Not Applicable

Completed

• Conditions: Alzheimer's disease

• Registration Number: ITMCTR2200005557
• Lead Sponsor: Chengdu Medical College

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

The diagnostic criteria of AD from the National Institute of Neurology, Speech and Stroke and the Association for AD and Related Disorders (NINCDS--ADRDA) were adopted:
(1) The presence of dementia was confirmed by survey scale and neuropsychological examination;
(2) =2 cognitive impairment;
(3) Progressive deterioration of memory and other cognitive functions;
(4) Unconscious disorder;
(5) Absence of systemic diseases or other encephalopathies that could explain memory and cognitive deficits.
(6) Clinical Dementia Rating Scale (CDR) =1.0 points.
Support the standard
(1) Progressive impairment of specific cognitive functions such as speech (aphasia), motor skills (apraxia) and perception (agnosia).
(2) Impairment of daily living functions or changes in behavior patterns.
(3) There is a family history of similar diseases, especially with neuropathological or laboratory evidence.
(4) The laboratory checked that the lumbar puncture pressure was normal;Normal or no special changes in eeg such as slow wave increase;Brain atrophy was confirmed by CT or MRI with progressive aggravation on follow-up examination.

Exclusion Criteria

(1) Patients with serious primary diseases whose conditions are complex and unpredictable;
(2) Patients with conscious disorder or mental illness who cannot cooperate with the examination, or with hearing impairment, visual impairment, aphasia, agnosia and other severe neurological defects that affect the functional evaluation;
(3) patients with severe dyspepsia, or gastrointestinal obstruction, or gastric and duodenal ulcers, and other gastrointestinal diseases that affect drug absorption;
(4) patients allergic to the drugs in the study;
(5) Patients with external treatment (such as acupuncture, physiotherapy, etc.).

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pittsburgh sleep quality index,PQSI;TCM symptom quantification score table;MMSE;Quality of Life-Alzheimer's Disease,QOL-AD;

Secondary Outcome Measures

Name	Time	Method
SF-36;The Neuropsychiatric Inventory-Questionnaire,NPI-Q;LMS;ADL;