PROPHYLACTIC INTRAVENOUS KETAMINE, ONDANSETRON AND PETHIDINE IN PREVENTING PERIOPERATIVE SHIVERING IN PATIENTS UNDERGOING ELECTIVE KNEE REPLACEMENT SURGERY UNDER SPINAL ANAESTHESIA: A RANDOMIZED PARALLEL-GROUP, PLACEBO CONTROLLED COMPARATIVE STUDY.

Phase 4

• Conditions: Post spinal shivering; Hypothermia, not associated with low environmental temperature; R68.0

• Registration Number: DRKS00023440
• Lead Sponsor: Army Hospital R&R Delhi India

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-12-12
• Study Start: 2020-11-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 216

Inclusion Criteria

American Society of Anesthesiologists (ASA) physical status I or II], aged (18-75 years), scheduled for Total Knee Replacement surgical operations under spinal anesthesia

Exclusion Criteria

2.Exclusion Criteria included patient refusal, ASA Grade > 2, Contraindications to spinal anesthesia, bleeding disorder, thyroid disease, Addison’s disease, Parkinson’s disease, Raynaud’s syndrome. History of convulsions/epilepsy, bronchial asthma, allergy to the agents to be used, blood transfusion during surgery, initial axillary temperature <36.0 or >37.5 °C , use of sedative-hypnotic agents, vasodilators, antidepressants therapy with selective serotonin reuptake inhibitors and monoamine oxidase inhibitors, benzodiazepines. or patients having inadequate Sub arachnoid blockade requiring supplementation by general anaesthesia

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prevention of shivering

Secondary Outcome Measures

Name	Time	Method
drug side effects