Using Open Contest and Neuro-influence Experiment to Develop and Evaluate PrEP Promotion Messages for High Risk Men

Not Applicable

Completed

• Conditions: HIV/AIDS
• Interventions: Behavioral: PrEP campaign messages developed via social marketing approach; Behavioral: PrEP campaign messages developed via open contest

• Registration Number: NCT04166851
• Lead Sponsor: Johns Hopkins Bloomberg School of Public Health

Brief Summary

The aim of this study is to examine the utility of neuroimaging technique to evaluate pre-exposure prophylaxis (PrEP) promotion messages for men who have sex with men (MSM) at risk of HIV in Baltimore.

Detailed Description

This study will examine the utility of neuroimaging technique to evaluate PrEP promotion messages for MSM at risk of HIV in Baltimore. The investigators hypothesize that participants viewing top messages developed via open contests will show higher brain activation in the Medial Prefrontal Cortex (MPFC) regions than those viewing messages developed by a social marketing approach. The investigators further hypothesize brain activation in the MPFC regions is significantly more correlated with PrEP behavioral intention, initiation, and action than self-reported message effectiveness.

Study Timeline

• Study First Submitted: 2019-10-23
• Study First Submitted QC: 2019-11-14
• Study Start: 2019-11-15
• Study First Posted: 2019-11-18
• Primary Completion: 2023-10-01
• Study Completion: 2023-10-30
• Status Verified: 2024-09
• Results First Submitted: 2024-09-26
• Results First Submitted QC: 2024-09-26
• Last Update Submitted: 2024-09-26
• Results First Posted: 2024-10-22
• Last Update Posted: 2024-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 23

Inclusion Criteria

• 18 years and older
• Biological male sex at birth
• Sexually active with men in the past 6 months
• Never taken PrEP
• HIV negative
• Reside in Baltimore City or surrounding counties
• Meet one of the criteria for being an appropriate PrEP candidate (i.e. in a relationship with a partner not known to be HIV-negative; are in a nonmonogamous relationship; have had any condomless anal sex with a casual male partner regardless of status in the prior 6 months; or had a positive sexual transmitted infection (STI) diagnosis within the prior 6 months).

Exclusion Criteria

• Participated in open contest

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Social marketing messages	PrEP campaign messages developed via social marketing approach	Participants will view the PrEP-promotion messages developed via social marketing.
Open contest messages	PrEP campaign messages developed via open contest	Participants will view the top PrEP-promotion messages developed via an open contest.

Primary Outcome Measures

Name	Time	Method
Change of Willingness to Take PrEP	baseline, 30 days post baseline	Questions on willingness to take PrEP. Participants will be asked, "Suppose that PrEP is at least 90% effective in preventing HIV when taken daily. How likely would you be to take PrEP if it were available for free?" with responses ranging from "Extremely unlikely-1," "Somewhat unlikely-2," "Somewhat likely-3," "Extremely likely-4." The mean of the changes between baseline and after participants reviewed the messages was calculated.

Trial Locations

Locations (1)

Johns Hopkins Bloomberg School of Public Health; 🇺🇸 Baltimore, Maryland, United States