Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Spontaneous Coronary Artery Dissection
- Sponsor
- Mayo Clinic
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Arterial stiffness
- Status
- Recruiting
- Last Updated
- 10 months ago
Overview
Brief Summary
The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.
Investigators
Marysia Tweet
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
- •For controls: no cardiac disease history
Exclusion Criteria
- •Pregnancy
- •Known or suspected unstable cardiac condition within 4 weeks of the study
- •Active treatment with anticoagulation or dual antiplatelet therapy
Outcomes
Primary Outcomes
Arterial stiffness
Time Frame: Baseline
Measured by carotid ultrasound pulse wave velocity reporting in m/s
Sympathetic response to stress
Time Frame: Baseline
Blood pressure or muscle sympathetic nerve activity response to sympathoexcitatory stressors (mm/Hg or bursts/min).
Arterial thickness
Time Frame: Baseline
Measured by carotid ultrasound intimal media thickness reporting in mm
Baroreflex sensitivity
Time Frame: Baseline
The slope between heart rate and blood pressure at rest and during the Valsalva Maneuver (ms/mmHg)