A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Not Applicable

Recruiting

• Conditions: Healthy; Spontaneous Coronary Artery Dissection

• Registration Number: NCT05699200
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-01-16
• Study First Submitted QC: 2023-01-16
• Study First Posted: 2023-01-26
• Study Start: 2023-06-01
• Status Verified: 2025-06
• Last Update Submitted: 2025-06-10
• Last Update Posted: 2025-06-12
• Primary Completion: 2027-08
• Study Completion: 2027-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
• For controls: no cardiac disease history

Exclusion Criteria

• Pregnancy
• Known or suspected unstable cardiac condition within 4 weeks of the study
• Active treatment with anticoagulation or dual antiplatelet therapy
• Prisoner

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Arterial stiffness	Baseline	Measured by carotid ultrasound pulse wave velocity reporting in m/s
Sympathetic response to stress	Baseline	Blood pressure or muscle sympathetic nerve activity response to sympathoexcitatory stressors (mm/Hg or bursts/min).
Arterial thickness	Baseline	Measured by carotid ultrasound intimal media thickness reporting in mm
Baroreflex sensitivity	Baseline	The slope between heart rate and blood pressure at rest and during the Valsalva Maneuver (ms/mmHg)

Trial Locations

Locations (1)

Mayo Clinic Rochester; 🇺🇸 Rochester, Minnesota, United States