Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Early Phase 1

Recruiting

• Conditions: Hypertension; Obesity
• Interventions: Drug: Neuropeptide Y

• Registration Number: NCT04838678
• Lead Sponsor: University of Texas Southwestern Medical Center

Brief Summary

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-04-06
• Study First Submitted QC: 2021-04-08
• Study First Posted: 2021-04-09
• Study Start: 2021-07-18
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-09
• Last Update Posted: 2024-08-12
• Primary Completion: 2025-09
• Study Completion: 2025-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Control - BMI<30, age 18-55
• Hypertensive - BMI<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI>30, age 18-55 Obese-hypertensive- BMI>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring

Exclusion Criteria

All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Healthy Control	Neuropeptide Y	Healthy age matched controls with no history of cardiovascular disease and normal bodyweight
Hypertensive	Neuropeptide Y	Hypertensive adults who are not obese
Obese	Neuropeptide Y	Obese adults who are not hypertensive
Obese-hypertensive	Neuropeptide Y	Obese adults who are being treated for hypertension

Primary Outcome Measures

Name	Time	Method
Muscle sympathetic nervous system activity	Acutely on the day of study	recording of sympathetic nervous system activity from the peroneal or radial nerve
Blood flow measured by doppler ultrasound	Acutely on the day of study	brachial and femoral artery blood flow

Trial Locations

Locations (1)

University of Texas Southwestern Medical Center; 🇺🇸 Dallas, Texas, United States