Sympathetic Neural Patterns and Transduction in Obesity-associated Hypertension
Overview
- Phase
- Early Phase 1
- Intervention
- Neuropeptide Y
- Conditions
- Hypertension
- Sponsor
- University of Texas Southwestern Medical Center
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Muscle sympathetic nervous system activity
- Status
- Recruiting
- Last Updated
- 8 months ago
Overview
Brief Summary
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.
Investigators
Christopher Hearon
Assistant Instructor
University of Texas Southwestern Medical Center
Eligibility Criteria
Inclusion Criteria
- •Control - BMI\<30, age 18-55
- •Hypertensive - BMI\<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI\>30, age 18-55 Obese-hypertensive- BMI\>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring
Exclusion Criteria
- •All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,
Arms & Interventions
Healthy Control
Healthy age matched controls with no history of cardiovascular disease and normal bodyweight
Intervention: Neuropeptide Y
Hypertensive
Hypertensive adults who are not obese
Intervention: Neuropeptide Y
Obese
Obese adults who are not hypertensive
Intervention: Neuropeptide Y
Obese-hypertensive
Obese adults who are being treated for hypertension
Intervention: Neuropeptide Y
Outcomes
Primary Outcomes
Muscle sympathetic nervous system activity
Time Frame: Acutely on the day of study
recording of sympathetic nervous system activity from the peroneal or radial nerve
Blood flow measured by doppler ultrasound
Time Frame: Acutely on the day of study
brachial and femoral artery blood flow