Role of the Sympathetic Nerve System for the Pathogenesis and Progression of Chronic Kidney Failure
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- sympathetic activation for the development and progression of chronic renal failure
研究概览
简要总结
The primary purpose is to assess the role of sympathetic activation for the development and progression of chronic renal failure. Using microneurography sympathetic activity will be registered in various stages of kidney affection or failure and hypertension.
A sympatholytic agent will be compared with a non-sympatholytic drug to asses the effect sympathetic activation and on the progression of kidney disease.
The effects of a sympatholytic agent on cardiovascular reactivity to various stressors wil be examined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •chronic renal failure stages I-IV
排除标准
- •pregnancy and lactation
- •severe heart failure or ischemic heart disease
- •patients with NYHA III-IV
研究组 & 干预措施
Arm 1
Rilmenidine as a sympatholytic agent for three months
干预措施: Rilmenidine (Drug)
Arm 2
Nitrendipine as a non-sympatholytic agent for three months
干预措施: Nitrendipine (Drug)
结局指标
主要结局
sympathetic activation for the development and progression of chronic renal failure
时间窗: 3 months
次要结局
- effects of a sympatholytic agent on cardiovascular reactivity to various stressors(3 months)