Sympathetic Nerve Activity in Renal Failure

Phase 4

Withdrawn

• Conditions: Hypertension; Chronic Kidney Disease
• Interventions: Drug: Rilmenidine; Drug: Nitrendipine

• Registration Number: NCT00892892
• Lead Sponsor: University of Erlangen-Nürnberg Medical School

Brief Summary

The primary purpose is to assess the role of sympathetic activation for the development and progression of chronic renal failure. Using microneurography sympathetic activity will be registered in various stages of kidney affection or failure and hypertension.

A sympatholytic agent will be compared with a non-sympatholytic drug to asses the effect sympathetic activation and on the progression of kidney disease.

The effects of a sympatholytic agent on cardiovascular reactivity to various stressors wil be examined.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-05-01
• Study First Submitted QC: 2009-05-01
• Study First Posted: 2009-05-05
• Study Start: 2009-11
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-16
• Last Update Posted: 2015-03-17

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• chronic renal failure stages I-IV

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Exclusion Criteria

• pregnancy and lactation
• severe heart failure or ischemic heart disease
• patients with NYHA III-IV

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Arm 1	Rilmenidine	Rilmenidine as a sympatholytic agent for three months
Arm 2	Nitrendipine	Nitrendipine as a non-sympatholytic agent for three months

Primary Outcome Measures

Name	Time	Method
sympathetic activation for the development and progression of chronic renal failure	3 months

Secondary Outcome Measures

Name	Time	Method
effects of a sympatholytic agent on cardiovascular reactivity to various stressors	3 months

Trial Locations

Locations (1)

University of Erlangen-Nuremberg, CRC, med. Clinic 4; 🇩🇪 Erlangen, Bavaria, Germany