NCT00567645
Withdrawn
Not Applicable
Identification of the Role of Sympathetic Innervation in Heart Failure Patients Treated With Cardiac Resynchronization Therapy. A Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sympathetic Innervation
- Sponsor
- University Medical Center Groningen
- Locations
- 1
- Primary Endpoint
- sympathetic innervation in patients with chronic heart failure (CHF)
- Status
- Withdrawn
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to assess whether baseline sympathetic innervation in patients with chronic heart failure (CHF) is predictive for response to cardiac resynchronization therapy (CRT). And to assess whether response to CRT coincides with restoration of regional sympathetic innervation.
Investigators
I.C. Van Gelder
Prof.dr.
University Medical Center Groningen
Eligibility Criteria
Inclusion Criteria
- •Indication for CRT
- •Stable optimal medication
- •Non ischemic cardiomyopathy
Exclusion Criteria
- •Age less then 18 years
- •Previous CRT
- •Clinically relevant valvular heart disease or coronary artery disease
- •Acute or chronic infection
- •Untreated clinical hypo- or hyperthyroidism or \< 3 months euthyroidism
- •Uncontrolled hypertension, defined as a systolic blood pressure \> 160 mm Hg and/or a diastolic blood pressure \> 95 mm Hg
- •A concurrent medical condition (i.e. alcohol or drug abuse or a severe progressive extra cardiac disease or M. Parkinson) or is unlikely to comply with the protocol
- •Participation to a previous protocol involving radioactivity in the past year
- •Pregnancy
Outcomes
Primary Outcomes
sympathetic innervation in patients with chronic heart failure (CHF)
Time Frame: 6 months
Secondary Outcomes
- NYHA class Echocardiographic parameters: LVEDD, LVESD, LVEF, LVESV,IVMD, and septal to lateral delay Hospitalization for heart failure Maximal oxygen consumption NT pro-BNP changes(6 months)
Study Sites (1)
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