Sympathetic Innervation of the Heart and Cardiac Resynchronization Therapy(CRT)
Withdrawn
- Conditions
- Chronic Heart FailureSympathetic Innervation
- Registration Number
- NCT00567645
- Lead Sponsor
- University Medical Center Groningen
- Brief Summary
The purpose of this study is to assess whether baseline sympathetic innervation in patients with chronic heart failure (CHF) is predictive for response to cardiac resynchronization therapy (CRT). And to assess whether response to CRT coincides with restoration of regional sympathetic innervation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Indication for CRT
- Stable optimal medication
- Non ischemic cardiomyopathy
Exclusion Criteria
- Age less then 18 years
- Previous CRT
- Clinically relevant valvular heart disease or coronary artery disease
- Acute or chronic infection
- Untreated clinical hypo- or hyperthyroidism or < 3 months euthyroidism
- Uncontrolled hypertension, defined as a systolic blood pressure > 160 mm Hg and/or a diastolic blood pressure > 95 mm Hg
- A concurrent medical condition (i.e. alcohol or drug abuse or a severe progressive extra cardiac disease or M. Parkinson) or is unlikely to comply with the protocol
- Participation to a previous protocol involving radioactivity in the past year
- Pregnancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method sympathetic innervation in patients with chronic heart failure (CHF) 6 months
- Secondary Outcome Measures
Name Time Method NYHA class Echocardiographic parameters: LVEDD, LVESD, LVEF, LVESV,IVMD, and septal to lateral delay Hospitalization for heart failure Maximal oxygen consumption NT pro-BNP changes 6 months
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways link sympathetic innervation to CRT response in chronic heart failure patients?
How does cardiac resynchronization therapy compare to standard ICD therapy in restoring sympathetic nerve activity in CHF?
Which biomarkers like MIBG uptake or norepinephrine levels predict CRT efficacy in CHF with sympathetic denervation?
What adverse events arise from CRT-induced autonomic nervous system modulation in heart failure populations?
Are there adrenergic receptor-targeting drugs that synergize with CRT to improve sympathetic innervation in CHF?
Trial Locations
- Locations (1)
University Medical Center Groningen
🇳🇱Groningen, Netherlands
University Medical Center Groningen🇳🇱Groningen, Netherlands