NCT00567645撤回不适用
Identification of the Role of Sympathetic Innervation in Heart Failure Patients Treated With Cardiac Resynchronization Therapy. A Pilot Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- sympathetic innervation in patients with chronic heart failure (CHF)
研究概览
简要总结
The purpose of this study is to assess whether baseline sympathetic innervation in patients with chronic heart failure (CHF) is predictive for response to cardiac resynchronization therapy (CRT). And to assess whether response to CRT coincides with restoration of regional sympathetic innervation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Indication for CRT
- •Stable optimal medication
- •Non ischemic cardiomyopathy
排除标准
- •Age less then 18 years
- •Previous CRT
- •Clinically relevant valvular heart disease or coronary artery disease
- •Acute or chronic infection
- •Untreated clinical hypo- or hyperthyroidism or < 3 months euthyroidism
- •Uncontrolled hypertension, defined as a systolic blood pressure > 160 mm Hg and/or a diastolic blood pressure > 95 mm Hg
- •A concurrent medical condition (i.e. alcohol or drug abuse or a severe progressive extra cardiac disease or M. Parkinson) or is unlikely to comply with the protocol
- •Participation to a previous protocol involving radioactivity in the past year
- •Pregnancy
结局指标
主要结局
sympathetic innervation in patients with chronic heart failure (CHF)
时间窗: 6 months
次要结局
- NYHA class Echocardiographic parameters: LVEDD, LVESD, LVEF, LVESV,IVMD, and septal to lateral delay Hospitalization for heart failure Maximal oxygen consumption NT pro-BNP changes(6 months)
研究者
I.C. Van Gelder
Prof.dr.
University Medical Center Groningen
研究点 (1)
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