Clinical Confirmation of a Pharmacodynamic Interaction Between Tropisetron and Paracetamol
Phase 4
Completed
- Conditions
- Pain
- Registration Number
- NCT00487110
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Brief Summary
A previous study has shown that tropisetron inhibits the analgesic effect of paracetamol in healthy volunteers. This study aims at confirming this pharmacodynamic interaction in patients with post-surgery pain.
- Detailed Description
The study is a comparison of the analgesic action of paracetamol versus tropisetron + paracetamol in 30 patients who had surgery of the ear. The evaluation criteria will be the score on the visual analogue scale for pain evaluation.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- More than 18 years
- Men or women
- Ear surgery
- Written consent given
Exclusion Criteria
- Paracetamol hypersensibility
- Tropisetron hypersensibility
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Visual analogue scale score will be taken at 30min, 1h, 2h, 3h and compared for the two groups at 30 min, 1h, 2h, 3h
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU
🇫🇷Clermont-Ferrand, France
CHU🇫🇷Clermont-Ferrand, France