A Randomized Controlled Clinical Trial on the Antipyretic Efficacy of Oral Paracetamol, Intravenous Paracetamol and Intramuscular Diclofenac in Patients Presenting With Fever to Emergency Department
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 434
- 试验地点
- 1
- 主要终点
- Reduction in temperature in every thirty minutes till 120 minutes after receiving antipyretics
研究概览
简要总结
A randomized clinical trial to check the antipyretic efficacy of oral and intravenous paracetamol and intramuscular diclofenac sodium in patients presenting with fever to emergency department.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 14 Years 至 75 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults between the age of 14-75 years with an oral temperature of more than 38.5 C
排除标准
- •History of allergy to any of the drugs in the study
- •Had taken antipyretics within 8 hours
- •Renal, hepatic or haematological disorders
- •bronchial asthma, peptic ulcer disease, vomiting
- •Pregnant or lactating women
研究组 & 干预措施
oral paracetamol
patients in this arm will receive 1000mg of oral paracetamol
干预措施: Oral paracetamol (Drug)
Intravenous paracetamol
patients in this arm will receive 1000 mg of intravenous paracetamol
干预措施: Intravenous paracetamol (Drug)
Intramuscular Diclofenac
patients in this arm will receive 75 mg of intramuscular diclofenac sodium
干预措施: Intramuscular diclofenac (Drug)
结局指标
主要结局
Reduction in temperature in every thirty minutes till 120 minutes after receiving antipyretics
时间窗: Reduction in temperature is checked every 30 minutes for a maximum of 120 minutes
Once the patients fulfill the inclusion criteria, they are randomly assigned to receive one of the three medications in the study ( oral paracetamol, intravenous paracetamol or intramuscular diclofenac). Baseline temperature is recorded using a standard thermometer. Then reduction in temperature is recorded every 30 minutes for 2 hours.
次要结局
未报告次要终点
研究者
Firjeeth C Paramba
Specialist, Emergency Department
Hamad Medical Corporation