Medication Reviews in Elderly in Primary Care

Not Applicable

Completed

• Conditions: Drug Utilization Review
• Interventions: Other: Medication review

• Registration Number: NCT04040855
• Lead Sponsor: Region Skane

Brief Summary

The study is a follow-up of a randomized controlled study performed in 2011-2012 with medication reviews in elderly patients in Sweden. Additional data about mortality and hospital admissions have been collected.

Detailed Description

Background Drug-related problems among the elderly population are common and increasing. Multi-professional medication reviews (MR) have arisen as a method to optimize drug therapy for frail elderly patients. Research has not yet been able to show conclusive evidence of the effect of MRs on mortality or hospital admissions. Aim The aim of this study was to assess the impact of MRs' on hospital admissions and mortality after six and 12 months in a frail population of 369 patients in primary care in a randomized controlled study. Methods Patients were blindly randomized to an intervention group (receiving MRs) and a control group (receiving usual care). Descriptive data on mortality and hospital admissions at six and 12 months were collected. Survival analysis was performed for time to death and time to the first hospital admission within 12 months.

Study Timeline

• Study Start: 2011-09-01
• Primary Completion: 2018-12-31
• Study Completion: 2019-03-31
• Status Verified: 2019-07
• Study First Submitted: 2019-07-29
• Study First Submitted QC: 2019-07-31
• Last Update Submitted: 2019-07-31
• Study First Posted: 2019-08-01
• Last Update Posted: 2019-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 369

Inclusion Criteria

• age>75 years, living in nursing homes or community-dwelling with municipality-provided care, with multi-dose drug dispensing

Exclusion Criteria

• lack of multi-dose drug dispensing, living at home with no municipality-provided care, <75 years old

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention	Medication review	Patients in the intervention groups received multi-professional medication reviews. A nurse performed a symptom evaluation, a pharmacist assessed the drug list and made adjustment suggestions and finally a physician took action and performed medication changes.

Primary Outcome Measures

Name	Time	Method
hospital admission	twelve months	time to the first hospital admission
Survival analysis	twelve months	time to death

Secondary Outcome Measures

Name	Time	Method
mortality	twelve months	number of deaths
number of hospital admissions	twelve months	number of hospital admissions