AMBITYON STUDY: the relation between inflammation cells, immune system cells and the development of arteriosclerosis: a study with MRI in young adults.
- Conditions
- atherosclerosis, MR Imaging, biomarkers, presence, progression, young adults
- Registration Number
- NL-OMON25569
- Lead Sponsor
- niversity Medical Center Utrecht
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 575
Inclusion Criteria
no medical history of cardiovascular disease and no cardiovascular preventive medication;
between 25-35 years of age;
Exclusion Criteria
subjects with claustrophobia;
subjects with a history of allergic reactions to MR contrast fluids;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method (a) presence and (b) rate of change in atherosclerosis over time in young adulthood (visualized with state-of the-art magnetic resonance imaging techniques) predicted by certain biomarkers of circulating cells and systemic inflammation
- Secondary Outcome Measures
Name Time Method aortic wall thickness and volume;<br /><br>presence and number of aortic atherosclerotic plaques (luminal protrusion of > 1 mm in radial thickness);<br /><br>the extent of aortic atherosclerosis (expressed as % of affected aorta as fraction of total aorta depicted)