The relation between inflammation cells and immune-system cells and the development of hardening of the arteries (arteriosclerosis), a research project with MRI in young adults
Recruiting
- Conditions
- development of subclinical arteriosclerosis in the young de ontwikkeling van subklinische atherosclerose in jonge volwassenen
- Registration Number
- NL-OMON27711
- Lead Sponsor
- niversity Medical Center Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 520
Inclusion Criteria
• no medical history of cardiovascular disease and no cardiovascular preventive medication;
• between 25-35 years of age;
Exclusion Criteria
• subjects with claustrophobia;
• subjects with a history of allergic reactions to MR contrast fluids;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -aortic wall thickness and volume;<br /><br>-presence and number of aortic atherosclerotic plaques (luminal protrusion of > 1 mm in radial thickness);<br /><br>-the extent of aortic atherosclerosis (expressed as % of affected aorta as fraction of total aorta depicted).
- Secondary Outcome Measures
Name Time Method -biomarkers of circulating cells;<br /><br>-plasma biomarkers of systemic inflammation (including micro particles)<br>