The Effect of Calcium on Fecal Fat and Energy Excretion

Not Applicable

• Conditions: Obesity
• Interventions: Other: Dairy calcium

• Registration Number: NCT00519909
• Lead Sponsor: University of Copenhagen

Brief Summary

The overall purpose of this study is to examine the effect of calcium on fecal fat and energy excretion.

Detailed Description

Several reports have found inverse associations between calcium intake and body weight. Few intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. The mechanism is not clear, but one possible explanation is reduced absorption of fat in the gut, due to formation of insoluble calcium fatty acid soaps or binding of bile acids which impairs the formation of micelles.

The aim of this study is to examined if a high calcium intake from dairy products, in diets high or normal in fat content, have an effect on fecal energy and fat excretion, concentrations of substrates involved in energy metabolism and blood pressure.

Study Timeline

• Status Verified: 2007-08
• Study Start: 2007-08
• Study First Submitted: 2007-08-22
• Study First Submitted QC: 2007-08-22
• Last Update Submitted: 2007-08-22
• Study First Posted: 2007-08-23
• Last Update Posted: 2007-08-23
• Study Completion: 2008-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

• healthy meals
• BMI 24-31 kg/m2
• age between 18-50 years

Exclusion Criteria

• donation of blood 6 months before and under the study
• milk allergy, diabetes, hypertension, hyperlipidemia, cronic infectious disease
• use of dietary supplements 3 months before and under the study
• smoking
• elite athletes
• use of medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
1	Dairy calcium	Diet with high content of calcium and high content of fat
2	Dairy calcium	Diet with low content of calcium and high content of fat
3	Dairy calcium	Diet with high content of calcium and normal content of fat
4	Dairy calcium	Diet with low content of calcium and normal content of fat
5	Dairy calcium	Diet with high content of calcium fra supplement and high content of fat

Primary Outcome Measures

Name	Time	Method
Fecal fat excretion, fecal energy excretion, calcium excretion, cholesterol

Secondary Outcome Measures

Name	Time	Method
Vitamin D, changes in lipolyse

Trial Locations

Locations (1)

Dept. of Human Nutrition, Faculty of Life Sciences, University of Copenhagen; 🇩🇰 Frederiksberg, Denmark