Effect of High-calcium Intake on Substrate Metabolism During Exercise

Not Applicable

Completed

• Conditions: Lipid Metabolism
• Interventions: Dietary Supplement: Calcium; Dietary Supplement: Placebo

• Registration Number: NCT01779245
• Lead Sponsor: Northumbria University

Brief Summary

A high-calcium intake can accelerate fat loss under energy-restricted diets. Part of this may be due to a shift in substrate metabolism where there is an increase in the rate of fat oxidation. However, whether high-calcium intake can influence substrate metabolism during exercise is not known. Accordingly, we aim to investigate the effect of 2 weeks of high-calcium intake on substrate metabolism during exercise.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10
• Study First Submitted: 2013-01-28
• Study First Submitted QC: 2013-01-29
• Study First Posted: 2013-01-30
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-04
• Last Update Posted: 2013-09-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 13

Inclusion Criteria

• Physically active (moderate-vigorous exercise >3 time per week)
• Male
• 18-40 yrs of age

Exclusion Criteria

• Smoker
• Known Food Allergies
• Metabolic disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High-Calcium	Calcium	A chocolate milkshake with a high calcium content will be consumed daily (235 kcal; 13 g protein; 42 g carbohydrate; 1 g fat, 1400 mg calcium per serving).
Control	Placebo	A chocolate milkshake with a normal calcium content will be consumed daily (235 kcal; 13 g protein; 42 g carbohydrate; 1 g fat, 400 mg calcium per serving).

Primary Outcome Measures

Name	Time	Method
Substrate metabolism	60 s samples every 3 min for 15 min	Substrate metabolism will be assessed by the respiratory exchange ratio (rate of carbon dioxide production/rate of oxygen consumption) from samples of expired gas collected during the first 15 minutes of an incremental cycling test.

Secondary Outcome Measures

Name	Time	Method
Plasma non-esterified fatty acid concentrations	Every 3 min for 15 min	Non-esterified fatty acid concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test to indicate fatty acid availability.
Plasma glycerol concentrations	Every 3 min for 15 min	Glycerol concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test as a marker of lipolysis.

Trial Locations

Locations (1)

Northumbria University; 🇬🇧 Newcastle upon Tyne, Tyne and Wear, United Kingdom