Influence of tDCS on Cortical Plasticity in Healthy Older Adults

Not Applicable

Withdrawn

• Conditions: Healthy Older Adults
• Interventions: Device: transcranial direct current stimulation; Device: sham stimulation

• Registration Number: NCT01888055
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).

Detailed Description

Not available

Study Timeline

• Study Start: 2013-05
• Study First Submitted: 2013-06-25
• Study First Submitted QC: 2013-06-26
• Study First Posted: 2013-06-27
• Primary Completion: 2017-10
• Study Completion: 2017-12
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-12
• Last Update Posted: 2021-05-14

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• right-handed according to the Oldfield Händigkeits inventory (lateralization index >70)(1971)
• no obvious cognitive impairment (MMSE>26, Demtect>13)
• age between 50 and 80 years

Exclusion Criteria

• Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
• Epilepsy, epileptic seizure in medical history
• Cognitive deficit (MMSE <20)
• Depressive episode (Beck Depression Inventory (BDI) > 12)
• intake of centrally active drugs <3 months , particularly acetylcholinesterase inhibitors
• Pregnancy
• Pacemaker (contraindication for MRI)
• Other metal parts in the body (contraindication for MRI)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
transcranial direct current stimulation	transcranial direct current stimulation	-
sham stimulation	sham stimulation	-

Primary Outcome Measures

Name	Time	Method
anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults	1 week	to investigate whether the anodal transcranial direct current stimulation over the primary motor cortex (M1) in healthy older adults increases cortical plasticity (measured via motor evoked potentials)compared to sham stimulation

Secondary Outcome Measures

Name	Time	Method
Comparison of tDCS-induced changes in the learning success	1 week	tDCS-induced changes on learning success (performance in a motor learning paradigm in healthy older adults after tDCS vs. sham)
Comparison of tDCS-induced changes on central cholinergic activity	1 week	to investigate weather anodal transcranial direct-current stimulation affect central cholinergic activity (measured via a TMS-protocol) in healthy older adults compared to sham stimulation
genetic polymorphism, ApoE4	once	optional assessment of genetic Apo4 epsilon status for assessment of differences in cortical plasticity and elasticity between Apo4 epsilon positive and negative participants
MR elastography	1 week	Comparison of viscoelastic parameters in cerebral MR elastography in healthy older adults

Trial Locations

Locations (1)

Klinik und Poliklinik für Neurologie, Charité Universitätsmedizin Berlin; 🇩🇪 Berlin, Germany