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Clinical Trials/NCT01888055
NCT01888055
Withdrawn
Not Applicable

Influence of Transcranial Direct-current Stimulation on Cortical Plasticity in Healthy Older Adults

Charite University, Berlin, Germany1 site in 1 countryMay 2013
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ConditionsHealthy Older Adults

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Healthy Older Adults
Sponsor
Charite University, Berlin, Germany
Locations
1
Primary Endpoint
anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults
Status
Withdrawn
Last Updated
4 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).

Registry
clinicaltrials.gov
Start Date
May 2013
End Date
December 2017
Last Updated
4 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Agnes Flöel

Prof. Dr.

Charite University, Berlin, Germany

Eligibility Criteria

Inclusion Criteria

  • •right-handed according to the Oldfield Händigkeits inventory (lateralization index \>70)(1971)
  • •no obvious cognitive impairment (MMSE\>26, Demtect\>13)
  • •age between 50 and 80 years

Exclusion Criteria

  • •Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
  • •Epilepsy, epileptic seizure in medical history
  • •Cognitive deficit (MMSE \<20)
  • •Depressive episode (Beck Depression Inventory (BDI) \> 12)
  • •intake of centrally active drugs \<3 months , particularly acetylcholinesterase inhibitors
  • •Pregnancy
  • •Pacemaker (contraindication for MRI)
  • •Other metal parts in the body (contraindication for MRI)

Outcomes

Primary Outcomes

anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults

Time Frame: 1 week

to investigate whether the anodal transcranial direct current stimulation over the primary motor cortex (M1) in healthy older adults increases cortical plasticity (measured via motor evoked potentials)compared to sham stimulation

Secondary Outcomes

  • Comparison of tDCS-induced changes in the learning success(1 week)
  • Comparison of tDCS-induced changes on central cholinergic activity(1 week)
  • genetic polymorphism, ApoE4(once)
  • MR elastography(1 week)

Study Sites (1)

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