Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Patients With Mild Cognitive Impairment (MCI)

Charite University, Berlin, Germany1 site in 1 countryMay 2013

ConditionsPatients With Mild Cognitive Impairment

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Patients With Mild Cognitive Impairment
Sponsor: Charite University, Berlin, Germany
Locations: 1
Primary Endpoint: the anodal transcranial direct current stimulation over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI)
Status: Withdrawn
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).

Registry

clinicaltrials.gov

Start Date

May 2013

End Date

December 2017

Last Updated

4 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Charite University, Berlin, Germany

Responsible Party

Principal Investigator

Agnes Flöel

Prof. Dr.

Charite University, Berlin, Germany

Eligibility Criteria

Inclusion Criteria

•Right-handed according to the Oldfield Händigkeits inventory (lateralization index\> 70) (1971)
•Cognitive impairment according to the diagnostic criteria of a MCI (amnesic or even multiple domains)
•No therapeutic treatment with AChE inhibitors
•No motor impairments relevant to everyday life
•Age 50 to 80 years

Exclusion Criteria

•Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
•Epilepsy, epileptic seizure in medical history
•Cognitive deficit (MMSE \<20)
•Depressive episode (Beck Depression Inventory (BDI)\> 12)
•Newly taking (\<3 months) centrally active drugs, particularly acetylcholinesterase inhibitors
•Pregnancy
•Pacemaker (contraindication for MRI)
•Other metal parts in the body (contraindication for MRI)

Outcomes

Primary Outcomes

the anodal transcranial direct current stimulation over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI)

Time Frame: 1 week

to investigate whether the anodal transcranial direct current stimulation over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) increases cortical plasticity (measured via motor evoked potentials) compared to sham stimulation