Prospective Study of Patients Treated for Prosthetic Hip Infection and Followed for at Least 2 Years
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Hip Prosthesis Infection
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
- Enrollment
- 347
- Locations
- 1
- Primary Endpoint
- Incidence of reinfection (relapse and new infection)
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Data from large prospective cohort studies of prosthetic joint infections are lacking.
Aim of this study: analyzing prospectively the incidence of reinfection in patients with prosthetic hip infections who underwent surgery and received antibiotic therapy.
Hypothesis: to confirm in a large group that the incidence of reinfection after excision -synovectomy in acute prosthesis hip infection is 30% and 15% for chronic infection after exchange arthroplasty (one or two stage exchange).
Detailed Description
Aim of the study: to analyze the incidence of reinfection in patients with prosthetic hip infection who underwent surgery and received antibiotic therapy Methods: prospective cohort study in a French referral center for osteoarticular infections from November 2002 to March 2010. Population * all patients who consented to participate in the study with prosthetic hip infections treated by: * debridement-synovectomy for acute infection or with one-stage or two-stage * exchange arthroplasty or resection arthroplasty for chronic infection * antibiotic therapy Outcome: * Follow-up: minimum of 2 years * Events monitored: reinfection including relapse and new infection, joint revision for mechanical reasons, prosthetic hip infection related and non-related deaths
Investigators
Dr Valerie ZELLER
Investigator coordinator
Groupe Hospitalier Diaconesses Croix Saint-Simon
Eligibility Criteria
Inclusion Criteria
- •Patients with hip arthroplasty infection
- •Surgical treatment: either debridement-synovectomy and prosthesis retention for acute infection or one or two-stage exchange arthroplasty or resection arthroplasty for chronic infection
- •Antibiotic therapy
- •Signed informed consent
Exclusion Criteria
- •Prolonged suppressive antibiotic therapy
- •No surgical treatment
Outcomes
Primary Outcomes
Incidence of reinfection (relapse and new infection)
Time Frame: 2 years
The aim of this study was to prospectively determine the incidence of reinfection in patients with prosthetic hip infection after two years of follow up.
Secondary Outcomes
- Incidence and causes of mechanical revision(2 years)
- Incidence and causes of death: infection or treatment related death, unrelated death(2 years)