Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 114
- 主要终点
- rate of treatment failure
研究概览
简要总结
This study concerns patients having had an infection on their prosthesis (hip, knee,..) and for whom a 2-step exchange of prosthesis has been done.
A 2-step exchange consists in explantation of the prosthesis and implementation of a spacer at the first stage, and reimplantation of a new prosthesis in a second stage. Patients with late prosthetic joint infection are at risk for superinfection at the time of reimplantation.
The aim is to determine the microbiological epidemiology in patients experiencing failure following reimplantation to establish, based on the drug susceptibilities, which cement could be the most active.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with prosthetic joint infection having had a 2-step exchange at least from the reimplantation, between 2013 and 2015.
排除标准
- 未提供
结局指标
主要结局
rate of treatment failure
时间窗: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption)
Treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin
次要结局
- rate of clinical failure(Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption))
- rate of bacteria involved in microbiological failure(Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption))
研究者
Eugénie MABRUT
Clinical Research Assistant
Hospices Civils de Lyon