Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Bone and Joint Infection
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 114
- Primary Endpoint
- rate of treatment failure
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
This study concerns patients having had an infection on their prosthesis (hip, knee,..) and for whom a 2-step exchange of prosthesis has been done.
A 2-step exchange consists in explantation of the prosthesis and implementation of a spacer at the first stage, and reimplantation of a new prosthesis in a second stage. Patients with late prosthetic joint infection are at risk for superinfection at the time of reimplantation.
The aim is to determine the microbiological epidemiology in patients experiencing failure following reimplantation to establish, based on the drug susceptibilities, which cement could be the most active.
Investigators
Eugénie MABRUT
Clinical Research Assistant
Hospices Civils de Lyon
Eligibility Criteria
Inclusion Criteria
- •patients with prosthetic joint infection having had a 2-step exchange at least from the reimplantation, between 2013 and 2015.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
rate of treatment failure
Time Frame: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption)
Treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin
Secondary Outcomes
- rate of clinical failure(Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption))
- rate of bacteria involved in microbiological failure(Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption))