CNS Correlates of Extended Sleep Restriction
- Conditions
- Sleep Restriction
- Registration Number
- NCT05547880
- Lead Sponsor
- Walter Reed Army Institute of Research (WRAIR)
- Brief Summary
Chronic sleep restriction is ubiquitous in both the general population and the military. The deleterious effects of sleep loss on human alertness and cognitive performance have been documented in numerous studies dating back to the nineteenth century. Over the past decade, evidence has emerged indicating that chronic sleep restriction may also precipitate deleterious, long lasting neuropathological changes in the brain. The purpose of this study is to determine neuropathological effects of sleep restriction and identify physiological mechanisms that correlate with sleep loss-induced performance impairment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Positron Emission Tomography (PET) based measurement of neuroinflammation 3 Days Positron Emission Tomography (PET) is the brain imaging method and \[11C\]ER176 is the PET radioligand providing an index of neuroinflammation
- Secondary Outcome Measures
Name Time Method Psychomotor Vigilance Task (PVT) 55 Days Measure of cognitive performance
Actigraphy 55 Days Activity monitoring used to infer sleep-wake patterns
Polysomnographic measurements of sleep and wakefulness 19 Days Measure of various aspects of sleep and wakefulness
Trial Locations
- Locations (1)
Walter Reed Army Institute of Research
🇺🇸Silver Spring, Maryland, United States