Post prandial muscle perfusion and protein metabolism in healthy young and elderly me

Completed

• Conditions: spiermetabolisme; Loss of muscle mass; 10018424

• Registration Number: NL-OMON35703
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 69

Inclusion Criteria

24 healthy, non obese (BMI<30 kg*m2), young male subjects (18-30 y) with with a stable body weight over the last 3 months.
24 healthy, non obese (BMI<30 kg*m2), elderly male subjects (65-75 y), with a stable body weight over the last 3 months

Exclusion Criteria

Hemoglobine level below 8.0 mmol/L
Cardiac abnormalities
Coagulation disorders
Vascular diseases
Obesity (BMI > 30 kg*m2)
Diabetes mellitus type 1 and type 2
Glucose intolerance
HbA1c > 7.0%
Diagnosed impaired renal or liver function
Smoking
All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders and paralysis)
Cancer
Hypertension
Acute or chronic pulmonary diseases
Allergy for lidocain or iodine
Use of NSAIDs and acetylsalicylic acid
Patients suffering from PKU (Phenylketonuria)
Infectious disease
Participation in any regular exercise program
Unstable body weight over the last 3 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint: Muscle protein synthesis rate, expressed as fractional<br /><br>synthetic rate (FSR). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints: Rate of protein digestion and absorption, whole body<br /><br>protein balance, femoral and leg blood flow and microvascular perfusion. </p><br>