Effect of Different Biomimetic Materials on White Spot Lesions in Enamel

Not Applicable

Completed

• Conditions: White Spot Lesion
• Interventions: Other: Time of assessment

• Registration Number: NCT05001035
• Lead Sponsor: Benha University

Brief Summary

This study will be conducted to evaluate: 1- The remineralizing effect of different biomimetic materials (Zinc carbonate hydroxyapatite nanoparticles, Poly-amido amine (PAMAM) and bioactive glass nanoparticles) on white spot lesions in enamel. 2- The clinical efficacy of these agents on disappearance of these white spots.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-01
• Study First Submitted: 2021-07-28
• Study First Submitted QC: 2021-08-06
• Study First Posted: 2021-08-11
• Primary Completion: 2021-09-18
• Study Completion: 2021-09-20
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-05
• Last Update Posted: 2021-10-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Total of 21 patients enrolled in this study will be selected having at least 4 teeth (one on each quadrant) which will be extracted for orthodontic treatment.
• These patients will be selected according to age groups between 15-25 years old
• good oral hygiene
• free of destroying habits for dental tissues

Exclusion Criteria

• Bruxism
• soft drinks consumption
• acid regurgitation, etc.).
• Selected teeth having any cracks, malformations, dysplasia or caries.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Zinc carbonated hydroxy apatite	Time of assessment	Toothpaste to be added on white spot lesions in dental enamel
Bioactive glass	Time of assessment	Toothpaste to be added on white spot lesions in dental enamel
Poly amido amine	Time of assessment	Resinous material to be painted on white spot lesions in dental enamel

Primary Outcome Measures

Name	Time	Method
change in remineralization from base line to time limit	Immediate and one month and two months	Change in its density in digital xray
changes of appearance from base line photograph to time limit	Immediate and one month and two months	White spots disappear on digital photography

Trial Locations

Locations (1)

Faculty of dental medicine for girls branch of Alazhar University; 🇪🇬 Cairo, Egypt