Effect of Self Assembling Peptide on White Spot Lesion
- Conditions
- White Spot Lesion of Tooth
- Interventions
- Drug: remineralizing agent
- Registration Number
- NCT03930927
- Lead Sponsor
- Raneen Ahmed
- Brief Summary
During re-mineralization of white spot lesion, Will biomimetic self-assembling peptides improve the re-mineralizating effect of the post orthodontic white spot lesion compared to fluoride-based delivery systems?
- Detailed Description
Conservative dentistry no longer prefers the "drill and fill" concept and advocates reversal of lesions via remineralization. . Remineralization is the process of restoring minerals - again, in the form of mineral ions - to the hydroxyapatite latticework structure. It is three-dimensional, and the lost ions must be replaced with ions having the exact same shape, size and the same electrical charge as those lost from the lattice.
Fluoride and self-assembling peptides have been used as adjuncts to enhance remineralization.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 32
- Patients with post orthodontic white spot lesion.
- Patients with good oral hygiene.
- Patients with good general health.
- Cooperative patients.
- Subjects who signed the informed consent.
- Patients with tetracycline pigmentation and dental fluorosis.
- Enamel cavitation.
- Disable patient.
- patient with any systemic disease or severe medical complications.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Fluoride Self Assembling peptide Comparator Self Assembling peptide Self Assembling peptide intervention Self Assembling peptide remineralizing agent intervention Fluoride remineralizing agent Comparator
- Primary Outcome Measures
Name Time Method Remineralizing process 6 months using DIAGNOpen.
- Secondary Outcome Measures
Name Time Method Visual assessment 6 months using ICDAS II