The Role of Resistance Exercise in Chronic Obstructive Pulmonary Disease Exacerbation

Not Applicable

Completed

• Conditions: Chronic Obstructive Pulmonary Disease
• Interventions: Other: Resistance training

• Registration Number: NCT01786928
• Lead Sponsor: University of Sao Paulo

Brief Summary

The purpose of this study is to determine whether resistance exercise are effective in combating the decline in muscle strength during an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).

Detailed Description

Acute exacerbations are common in patients with COPD and cause specific signs and symptoms, such as increased dyspnea, productive cough with altered sputum, and fever. With disease progression, exacerbations are frequent and have a negative impact on health related quality of life and pulmonary function as well as increase mortality. More severe exacerbations require hospitalization resulting in enormous health expenditures, severely reducing daily life activities and declining peripheral muscle strength that can be only partially reversed after 3 months. Despite many features have been pointed out as responsible for the decrease in muscle strength during hospitalization, physical inactivity seems the most important.

Resistance training is an interesting therapeutic option to prevent and/or reverse muscular dysfunction due to immobilised in healthy subjects and stable COPD patients because induces hypertrophy of type II fibers, increases muscle strength and exercise tolerance. In addition, provokes lower dyspnea perception during effort compared with other exercise training. Despite these benefits for stable COPD, the impact of a resistance exercise program during hospitalization remains poorly known.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2009-04
• Primary Completion: 2009-12
• Study Completion: 2010-10
• Study First Submitted: 2012-01-10
• Status Verified: 2013-02
• Study First Submitted QC: 2013-02-05
• Last Update Submitted: 2013-02-05
• Study First Posted: 2013-02-08
• Last Update Posted: 2013-02-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• patients hospitalized for exacerbation of COPD

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Exclusion Criteria

• patients presenting change in mental status (confusion, lethargy or coma)
• persistence or worsening in hypoxemia (PaO2<40mmHg) and/or respiratory acidosis (pH<7.25) despite oxygen supplementation or use of non-invasive ventilation
• hemodynamic instability requiring vasoactive drugs
• patients transferred to ICU
• hospitalization lower than 5 days
• diseases that prevented the exercises

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
resistance training	Resistance training	resistance training of the upper and lower limbs, two series of 80% of repetition maximum test

Primary Outcome Measures

Name	Time	Method
The benefits of resistance training during exacerbation of COPD on peripheral muscle strength during hospitalization	Will be evaluated on the second day of hospitalization, the day of hospital discharge (this time interval must be longer than five days)	The metric used to evaluate the strength gain is given in kilogram (absolute value) and percentage relative to that obtained on the second hospital day

Secondary Outcome Measures

Name	Time	Method
The benefits of resistance training during exacerbation of COPD on physical activity in daily life	Will be evaluated in the third and fifth day of hospitalization and thirty days after discharge	The metric used to evaluate the changes will be given in minutes and percentage of total time

Trial Locations

Locations (1)

University Hospital of sao paulo; 🇧🇷 São Paulo, Brazil