3/7 Resistance Training Method in Cardiac Rehabilitation of Coronary Artery Disease and Heart Failure With Reduced Ejection Fraction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 112
- 试验地点
- 2
- 主要终点
- Change in Peak VO2 after 3 months
研究概览
简要总结
Aim of the clinical monocentric study is to assess the resistance training exercise intervention in patients with Heart Failure with reduced Ejection Fraction (HFrEF) and coronary artery disease that will best improve peak oxygen uptake (Peak Vo2) and leg strength (assessed Isokinetic). The investigators hypothesize that resistance training exercise with induced a high stress metabolic is more important exercise with induced than a lower stress metabolic.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical Coronary artery diseases
- •Heart failure with reduced ejection fraction
排除标准
- •acutely decompensated heart failure
- •electrocardiographic evidence of ischemia
- •significant valvular disease
- •orthopedic/neurologic disorders that limited exercise
结局指标
主要结局
Change in Peak VO2 after 3 months
时间窗: Baseline and 3 months
Change in Peak oxygen consumption (VO2) after three 3 months intervention
Change in strength knee extensor after 3 months
时间窗: Baseline and 3 months
Change in strength knee extensor (60°/sec) after three months intervention
次要结局
- Change in leg lean mass after 3 months(Baseline and 3 months)
- Change in submaximal exercise capacity after 3 months(Baseline and 3 months)
- Change in bone mass after 3 months(Baseline and 3 months)
- Change in 120°/sec strength knee extensor after 3 months(Baseline and 3 months)
- Change in lean mass after 3 months(Baseline and 3 months)
- Change in VE/VCO2 slope after 3 months(Baseline and 3 months)
- Change in workload maximal after 3 months(Baseline and 3 months)
- Change in hand grip force after 3 months(Baseline and 3 months)
- Change in resting heart rate variability at rest after 3 months(Baseline and 3 months)
- Change 30 s sit-to-stand after 3 months(Baseline and 3 months)
- Change in Body fat after 3 months(Baseline and 3 months)
- Change in Visceral adipose tissue after 3 months(Baseline and 3 months)
- Change in isometric strength knee extensor after 3 months(Baseline and 3 months)
- Change in ventilation metaboreflex function after 3 months(Baseline and 3 months)
- Change in diastolic blood pressure metaboreflex function after 3 months(Baseline and 3 months)
- Change in heart rate at rest after 3 months(Baseline and 3 months)
- Change in 180°/sec strength knee extensor after 3 months(Baseline and 3 months)
- Change strength knee extensor in leg extension after 3 months(Baseline and 3 months)
- Change in sub maximal strength knee extensor in leg extension after 3 months(Baseline and 3 months)
- Change in heart rate recovery after 3 months(Baseline and 3 months)
研究者
Alexis Gillet
Principal Investigator
Université Libre de Bruxelles