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临床试验/NCT02435667
NCT02435667已完成不适用

Resistance Exercise Training in Heart Failure With Preserved Ejection Fraction (Resist - HFpEF)

Mayo Clinic2 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2015年6月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
Mayo Clinic
入组人数
24
试验地点
2
主要终点
Bone density and strength

研究概览

简要总结

The objective of this proposal is to determine the effect of resistance exercise training on locomotor muscle function, exercise capacity, exertional symptoms, and quality of life in HF patients with preserved ejection fraction (HFpEF).

详细描述

In this randomized controlled pilot study of resistance exercise training in patients with HFpEF, the investigators will recruit 24 HFpEF patients who will be randomized to resistance exercise training (RT - n=12) or no resistance exercise training (standard care control group [CTL] - n=12). The investigators will have baseline and follow-up measures of clinical characteristics, leg muscle strength, quality of life, lean muscle mass (body composition via DXA including segmental lean mass), maximal cardiopulmonary exercise test (peak VO2, peak work, ventilatory efficiency), constant-load submaximal cardiopulmonary exercise test with speckle tracking echocardiography (exertional dyspnea and fatigue at matched workloads, cardiac output, diastolic function, left ventricular strain, ventilation, gas exchange, and locomotor muscle neural feedback).

Participants will be asked to make 4 separate study visits. Those randomized to undergo Resistance Training will be expected to make those visits as well.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Supportive Care
盲法
None

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Bone density and strength

时间窗: 12 weeks

DEXA scan

Cardiopulmonary Function

时间窗: 12 weeks

Cardiopulmonary bike exercise

Quality of Life

时间窗: 12 weeks

Questionnaire

Blood Biomarkers

时间窗: 12 weeks

Blood draw

次要结局

未报告次要终点

研究者

发起方
Mayo Clinic
申办方类型
Other
责任方
Principal Investigator
主要研究者

Thomas P. Olson, M.S., Ph.D.

Principal Investigator

Mayo Clinic

研究点 (2)

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