Effect of Birth on Immunological Parameters in Cord Blood
- Conditions
- Immunologic Activity Alteration
- Registration Number
- NCT03134768
- Lead Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
- Brief Summary
The purpose of the study is to understand the immediate effect of birth on immunological parameters in vaginally born cord blood.
- Detailed Description
The main purpose of the study is to understand the immediate effect of birth on immunological parameters in vaginally born cord blood and also whether mode and duration of delivery has an influence on immune parameters in cord blood.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 50
- Pregnant mothers undergoing normal vaginal delivery
-
Use of non-steroidal anti-inflammatory drugs (NSAIDs) 2 weeks prior to birth
- Antenatal antibiotics treatment (2 weeks prior to birth)
- Diabetes mellitus requiring insulin treatment during pregnancy
- Uncontrollable Hyperthyroidism during pregnancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Allergen Stimulated Cytokine Expression in the Supernatants of Cord Blood Mononuclear Cells (CBMC) 1 year Cellular response to allergen stimulation will be measured in supernatants of cultured cord blood mononuclear cells.
Cytokines Profile in Cord Blood Plasma 1 year Following cytokines will be part of the profile: IL-6, IL-1, IL-2, IL-4, IL-5, IL-7, IL-8, IL-10, IL12p70, IL-13, IL-17, G-CSF, GM-CSF, IFNg, MCP-1(MCAF), MIP-1b, TNFa
Cord Blood Immunoglobulin Levels 1 year Immunoglobulin levels will be measured in cord blood plasma
- Secondary Outcome Measures
Name Time Method