The effect of sevoflurane and isoflurane on vasopressor need

Phase 4

Completed

• Conditions: hypotension; low blood pressure; 10011954

• Registration Number: NL-OMON32879
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 35

Inclusion Criteria

Minimal of 18 years of age.
Patients undergoing coronary artery bypass grafting with the use of the cardiopulmonary bypass.

Exclusion Criteria

Valve surgery. Combined surgical procedures. Uncontrolled hypertension. Poor left ventricular function (left ventricular ejection fraction < 30%). Renal failure. BMI > 25. History of cerebrovascular accident, transient ischemic attack or carotid artery stenosis. Participation in an other study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome measure is the total amount of the vasopressor phenylephrine<br /><br>that is needed to maintain blood pressure above 60 mmHg during 10 minutes of<br /><br>CPB.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures are mean blood pressure throughout the 10 minute<br /><br>periods, the need for a stronger vasopressor (norepinephrine) and the inability<br /><br>to keep mean blood pressure below 75 mmHg at MAC 0.6.</p><br>