Comparative study of isoflurane and sevoflurane on recovery profile and; BP and Heart rate changes in patients undergoing neurosurgery
Not Applicable
- Conditions
- Health Condition 1: G988- Other disorders of nervous system
- Registration Number
- CTRI/2024/01/062032
- Lead Sponsor
- A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 36
Inclusion Criteria
1. Patients undergoing intracranial neurosurgery under general
anaesthesia and maintained on either isoflurane or sevoflurane
2. American Society of Anaesthesiologist (ASA) grade I or II
Exclusion Criteria
1. Diagnosed patients of pituitary adenoma on CT
2. Previous History of neurosurgery
3. History suggestive of allergies to isoflurane or sevoflurane
4. Patients with comorbidities like Hypertension and Diabetes
Mellitus.
5. Pregnant women
6. Patients with history of malignant hyperthermia, preexisting
renal insufficiency, Hepatic disease, Endocrine disease,
Neurological abnormality and electrolyte abnormalities
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Recovery end-points were measured as the time from closure of anesthesia to various time intervals <br/ ><br>of the anaesthetic vaporizer. <br/ ><br>• Difference in patients achieving recovery profileTimepoint: NA
- Secondary Outcome Measures
Name Time Method 1. Difference in the Blood pressure and Heart Rate of isoflurane <br/ ><br>and sevoflurane from baseline to various time intervals <br/ ><br> <br/ ><br>2. To assess the safety of isoflurane and sevoflurane in terms of <br/ ><br>adverse events (alteration of hemodynamics and adverse drug <br/ ><br>reaction)Timepoint: 1 Blood Pressure and Heart Rates were measured (1hour,2hour,3hour,4hour,5hour) intraoperatively <br/ ><br>2 Adverse events were seen perioperatively and postoperatively upto 2 hours <br/ ><br>