Prospective Study of the Impact of Systemic Corticosteroid Use on Measures of Sleep Disordered Breathing
Completed
- Conditions
- Sleep Apnea
- Registration Number
- NCT01228695
- Lead Sponsor
- Rambam Health Care Campus
- Brief Summary
Weight gain is both a significant risk factor for obstructive sleep apnea and a side-effect of long-term systemic steroids therapy.
This study aimed to investigate the impact of long-term systemic steroid treatment on sleep apnea.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- For inclusion, a scheduled therapy with a minimum daily dose of 10 mg prednisone (or equivalent) for at least 3 months was required
Exclusion Criteria
- Patients younger than 18 years and those with known sleep apnea or other forms of sleep-disordered breathing were excluded
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method apnea-hypopnea index 3 months
- Secondary Outcome Measures
Name Time Method sleep study variables 3 months apnea-hypopnea interval desaturation at the end of apnea interval snoring intensity
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link systemic corticosteroids to obstructive sleep apnea progression?
How do systemic corticosteroids compare to standard-of-care treatments in managing sleep apnea-related weight gain?
Are there specific biomarkers that predict corticosteroid-induced sleep apnea exacerbation in patients?
What adverse events are associated with long-term corticosteroid use in sleep apnea patients and how are they managed?
What combination therapies or alternative drugs can mitigate corticosteroid-induced sleep apnea risks?
Trial Locations
- Locations (1)
Rambam health care campus
🇮🇱Haifa, Israel
Rambam health care campus🇮🇱Haifa, Israel