Effects of ischemic remote conditioning on clinical outcomes in patients with coronary heart disease

Phase 1

Recruiting

• Conditions: Patients with heart failure or ischemic heart disease

• Registration Number: JPRN-UMIN000006460
• Lead Sponsor: niversity of Yamanashi

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-10-03
• Study Completion: 2016-09-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Not provided

Exclusion Criteria

Patients are excluded with following exclusion criteria. (1) Patients on Hemodialysis therapy and with blood access on upper arm. (2) Patients with severe complications and malignancy. (3) Patients with decreased blood flow or trauma on upper arm.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All enrolled patients are prospectively followed up for 5 years or until the occurrence of cardiac events. Cardiac events include cardiac death, hospitalization with heart failure, arrhythmia, non-fatal myocardial infarction, unstable angina required coronary revascularization.

Secondary Outcome Measures

Name	Time	Method
Endothelial function of brachial artery (FMD), intima-media thickness (IMT) of carotid arteries, %fractional shortning and %ejection fraction measured by cardiac ultrsaound are evaluated at the enrollment, 1 week, and 1 months after enrollment. Blood sampling are preformed at the enrollment, 1 week and 1 month after enrollment for measurement of inflammatory markers, and angiogenic factors.