Role of Peripheral Vision in Scene Perception (PERISCE)

Not yet recruiting

• Conditions: Primary Open-angle Glaucoma (POAG)
• Interventions: Behavioral: Psychophysical evaluation

• Registration Number: NCT05539508
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the scene and objects (deciding, for example, whether it is an urban or natural landscape). This first representation would then trigger predictive mechanisms which would subsequently guide a more detailed visual analysis in central vision. The psychophysical studies that the investigators have already conducted in this scientific context has been carried out under normal vision conditions. The objective of this project is to study the influence of peripheral vision on central vision with an original approach: What are the consequences of a loss of peripheral vision on the processing performed in central vision? The project will concern patients with glaucoma. This ophthalmic pathology particularly affects the peripheral retina and thus represents a good pathological cognitive model of a visual recognition system in which peripheral vision is less important. The investigators will conduct psychophysical studies with glaucomatous patients and healthy volunteers with normal vision. All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. Participants will have to perform various tasks on these images using the keys on the keyboard.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-08
• Study First Submitted: 2022-08-23
• Study First Submitted QC: 2022-09-13
• Last Update Submitted: 2022-09-13
• Study First Posted: 2022-09-14
• Last Update Posted: 2022-09-14
• Study Start: 2022-10-01
• Primary Completion: 2026-07-01
• Study Completion: 2027-07-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

For patients :

• between 18 and 80 years old
• stable bilateral primary open angle glaucoma (POAG)
• visual acuity > 5/10 for distant vision for the eye tested
• peripheral visual field defect on the eye tested measured through a Humphrey Visual Field Analyzer

For healthy volunteers :

• between 18 and 80 years old
• visual acuity > 5/10
• absence of ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy ...)

Exclusion Criteria

• ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy ...)
• treated with medication that might compromise sustained attention (benzodiazepine, narcoleptics)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Primary open-angle glaucoma (POAG) group	Psychophysical evaluation	-
Age-matched normally sighted control group	Psychophysical evaluation	-

Primary Outcome Measures

Name	Time	Method
Psychophysical measure : Percentage of correct response	Through study completion of 45 months	Measure calculated by the comparison between the expected response and the response provided by the participant for each trial of the experiment
Psychophysical measure : Mean reaction time in milliseconds	Through study completion of 45 months	Measure calculated by averaging the time in milliseconds taken by the participant to provide the response for each trial of the experiment