Median Sevoflurane Concentration for Hypotension Between Young and Elderlypatients: Adaptive Clinical Trial
- Registration Number
- NCT03595319
- Lead Sponsor
- Brasilia University Hospital
- Brief Summary
Two arms: elder group, young group. Dixon's up and down adaptive methodology for ED50. Executed after Anesthesia induction for 10min without touching the patient after starting mechanical ventilation.
- Detailed Description
This adaptive clinical trial will vary target end tidal sevoflurane by 0.4, then by 0.2 and by 0.1 thereafter in order to minimize sample size.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Understands experiment, is voluntary, signs informed consent;
- Does not take medication that influences arterial pressure;
- Normotensive.
Exclusion Criteria
- Received any medication that influences arterial pressure before experiment;
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Elder patients Sevoflurane Older than 65 Young patients Sevoflurane Patients between 19 and 40 years-old
- Primary Outcome Measures
Name Time Method Hypotension incidence related to sevoflurane During the first 10 minutes after end tidal sevoflurane concentration stabilizes Any mean arterial pressure drop \> 10% compared to baseline
- Secondary Outcome Measures
Name Time Method Systolic hypotension During the first 10 minutes after end tidal sevoflurane concentration stabilizes Systolic arterial pressure drop \>10%
Diastolic hypotension During the first 10 minutes after end tidal sevoflurane concentration stabilizes Systolic arterial pressure drop \>10%
Trial Locations
- Locations (1)
Hospital Universitário de Brasilia
🇧🇷Brasilia, Distrito Federal, Brazil