Effect of hypothermic irrigation solution on central corneal thickness after cataract surgery

Phase 3

• Conditions: decreasing the heat produced from phacoemulsification tip by using hypothermic irrigation solution will deceased the damage on cornea.; hypothermic irrigation solution; decreased temperature irrigation solution; phacoemulsification; cataract surgery; corneal edema; corneal damage; central corneal thickness; endothelial cell loss; post-operative inflammation

• Registration Number: TCTR20210517003
• Lead Sponsor: Research funds, Faculty of medicine, Khon Kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-17
• Study Completion: 2023-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: nknown
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

1. patients of out patient unit, ophthalmology department, Srinagarind Hospital who are diagnosed nuclear cataract grade 2-3 according to WHO/PBD cataract grading
2. age between 18-80 years old

Exclusion Criteria

1. those who has already been a participant of the study for another eye
2. those who has been diagnosed any of these following conditions in the eye that plan for the surgery ; glaucoma, shallow anterior chamber, pseudoexfoliation syndrome, any ocular diseases that have effect on endothelial cells, uveitis, previous intraocular surgery, pterygium that involve area of central corneal thickness or scar of pteryium excision that involve area of central corneal thickness, previous ocular trauma, infection, autoimmune disease, other ocular disease, currently on any ocular medications.
3. those whose endothelial cell counts are less than 1500 cells per squaremillimeter
4. those whose central corneal thickness is more than 600 micrometer
5. those who is diagnosed severe dry eye grade 3-4 according to DEWS definition and classification
6. those who is diagnosed complicated cataract.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mean central corneal thickness post operation 1 day anterior segment optical coherence tomography

Secondary Outcome Measures

Name	Time	Method
mean central corneal thickness post operation day 7 anterior segment optical coherence tomography,mean central corneal thickness post operative day 30 anterior segment optical coherence tomography,endothelial cell density loss post operative day 7 corneal confocal microscopy,endothelial cell density losss post operation day 30 corneal confocal microscopy,anterior chamber inflammation post operation day 1 Slit lamp examination,anterior chamber inflammation post operation day 7 slit lamp examination,anterior chamber inflammation post operation day 30 slit lamp examination,visual acuity post operative day1 snellen chart,visual acuity post operative day 7 snellen chart,visual acuity post operation day 30 snellen chart