Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome

Terminated

• Conditions: Cushing's Syndrome; Insulin Resistance
• Interventions: Procedure: Surgery

• Registration Number: NCT00682084
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose of this study is to investigate the effect og chronic elevated levels of cortisol on metabolism and insulin sensitivity.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-04
• Study First Submitted: 2008-05-20
• Study First Submitted QC: 2008-05-20
• Study First Posted: 2008-05-22
• Status Verified: 2014-12
• Primary Completion: 2016-11
• Study Completion: 2016-11
• Last Update Submitted: 2017-12-21
• Last Update Posted: 2017-12-22

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

• Written consent
• Age between 18 and 70
• Diagnosed with Cushing's syndrome

Exclusion Criteria

• Suspected malignancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	Surgery	Patients recently diagnosed with Cushing's syndrome

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity	Before and after treatment

Secondary Outcome Measures

Name	Time	Method
Glucose tolerance, QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism.	Before and after treatment

Trial Locations

Locations (1)

Department of Endocrinology; 🇩🇰 Aarhus C, Aarhus, Denmark