Effect of Circadian Timing of a Standardized Meal on Postprandial Glucose Response in Healthy Adults
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- King Faisal University
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- Incremental Area Under the Curve (iAUC) for Postprandial Glucose
Overview
Brief Summary
This randomized crossover study aims to investigate the effect of circadian timing of a standardized meal (morning versus evening consumption) on postprandial glucose response in healthy adults. Postprandial glucose will be assessed using the incremental area under the curve (iAUC) over 120 minutes.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy adults aged 18 years and older
- •Able and willing to provide informed consent
- •Able to comply with study procedures
Exclusion Criteria
- •Diagnosis of diabetes or any metabolic disorder affecting glucose regulation
- •Use of any medications
- •Pregnant or breastfeeding women
- •Night shift workers or individuals with irregular sleep patterns
Arms & Interventions
Morning Meal Condition
Participants will consume a standardized test meal in the morning following an overnight fasting period of at least 8 hours. Postprandial glucose will be measured over 120 minutes.
Intervention: Standardized Test Meal (Other)
Evening Meal Condition
Participants will consume the same standardized test meal in the evening following a standardized fasting period of at least 8 hours prior to the test meal. Postprandial glucose will be measured over 120 minutes.
Intervention: Standardized Test Meal (Other)
Outcomes
Primary Outcomes
Incremental Area Under the Curve (iAUC) for Postprandial Glucose
Time Frame: Baseline to 120 minutes after consumption of the standardized test meal
The primary objective of this study is to investigate the effect of circadian timing of a standardized test meal (morning versus evening consumption) on postprandial glucose response in healthy adults, assessed as the incremental area under the curve (iAUC) for capillary blood glucose over 120 minutes following meal consumption
Secondary Outcomes
- Peak Postprandial Glucose (Morning vs Evening)(Baseline to 120 minutes after consumption of the standardized test meal)
- Time to Peak Glucose (Morning vs Evening)(Baseline to 120 minutes after consumption of the standardized test meal)
- Postprandial Glucose Profile (Morning vs Evening)(Baseline, 15, 30, 60, 90, and 120 minutes after consumption of the standardized test meal)