Attenuation of Haemodynamic Responses to Laryngoscopy and Endotracheal Intubation with Intravenous Dexmedetomidine between two Doses : A Randomized Double Blind Prospective Study
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- HR and NIBP are more stable following laryngoscopy and intubation with Inj.Dexmedetomidine 0.5%
研究概览
简要总结
The augmented cardiovascular reflexes in the form of tachycardia and hypertension brought about by the noxious stimulus of laryngoscopy and intubation can prove to be detrimental for patients with cardiovascular and cerebrovascular diseases.This study was undertaken with different doses of dexmedetomidine and comparing it with two different doses to arrive at an optimal dose of dexmedetomidine for attenuation of stress response to laryngoscopy and endotracheal intubation.
Inj.Dexmedetomidine has been studied by few authors in a dose of 0.75 , 0.5 and 1mcg/kg. No study has been done to see the efficacy of dexmedetomidine in a dose of 0.3mcg/kg for attenuation of laryngoscopy and intubation response. Hence, in this study, we chose to include injection dexmedetomidine in a dose of 0.3 and 0.5 mcg/kg and compare for attenuation of laryngoscopy and intubation response.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •American Society of Anesthesiologists Physical Status 1 Patient posted for elective surgeries under general anesthesia.
排除标准
- •Patient who were physically dependent on narcotics, those with a history of bronchial asthma, drug or alcohol abuse, known drug allergy to either clonidine or dexmedetomidine.
- •Any predicted difficult airway.
结局指标
主要结局
HR and NIBP are more stable following laryngoscopy and intubation with Inj.Dexmedetomidine 0.5%
时间窗: parameters recorded will be HR, SBP, DBP and MAP at 1, 3 and 5 min after intubation.
次要结局
- compare the adverse effect & complication of the drug & their doses like hypotension & bradycardia.(During drug infusion hemodynamics monitoring for 10 minutes)
研究者
Chethan P L
Sapthagiri Institute of Medical Sciences and Research Centre