Fitness Assessment in Young Adults Recovered From Lymphoma or Hodgkin's Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Young Adults
- Sponsor
- University Hospital, Clermont-Ferrand
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- fat oxidation rate
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Regular physical activity (PA) is associated with maintaining body composition, increased cardiorespiratory capacity, muscle mass and bone mineral density. In the event of a cancer, the development of physical capacities and metabolism may therefore be disturbed by cancer, these associated treatments (chemotherapy, radiotherapy and hematopoietic stem cell transplantation) but also undernutrition and the reduction in physical activity or even a sedentary lifestyle.
Although the benefits of PA in oncology are now well identified for adult populations, studies are still rare in the population of children, adolescents and young adults, and the results are still difficult to generalize. As a result, there is no recommendation on the practice of physical activity in pediatric oncology or adolescents and young adults and the levels of physical activity of cured patients remain lower than those of the general population.
Fitness is a marker of health in adults as well as in adolescents. Physical condition is a set of components such as cardiorespiratory capacity (transport and use of O2), body composition (distribution of bone, muscle and fat masses) and muscle function (strength, power, fatigue, energy metabolism) .
The investigators hypothesize that, compared to young adults, recovered from lymphoma are expected to exhibit impaired physical condition, due to physical deconditioning.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Young adult male or female, aged 18 to 25
- •giving free and informed consent
- •Hodgkin lymphoma or non-Hodgkin lymphoma in the healing stage
- •Cured (defined by an undetectable disease at the end of treatment) for at least one year and maximum 6 years of lymphoma or Hodgkin's disease
Exclusion Criteria
- •Legal incapable adults
- •People under judicial protection
- •Treatment with systemic glucocorticoids for more than a week, during the 30 days preceding the tests
- •Medical contraindication to the practice of physical exercise
- •Any pathologies (other than the history of lymphoma for the cases) likely to affect the metabolism or the muscle mass
- •Any treatment that may have an influence on the energy metabolism
- •Active infection
- •Pregnant, breastfeeding, or likely to be
- •Subject's refusal to participate
Outcomes
Primary Outcomes
fat oxidation rate
Time Frame: day at 11:30 am during one day
maximum rate of lipid oxidation (in mg/ml)
Secondary Outcomes
- physical capacity(at 08:45 am during one day)
- sedentary level(from day 2 to day 5)
- blood N-terminal pro-B natriuretic peptide(at 07:30 am in fasted condition during one day)
- Body composition: fat(at 07:30 am during one day)
- blood insulinemia(at 07:30 am in fasted condition during one day)
- physical activity level(from day 2 to day 5)
- rest metabolism(at 08:00 am in fasted condition during one day)
- blood troponin(at 07:30 am in fasted condition during one day)
- blood lipids(at 07:30 am in fasted condition during one day)
- blood glucose(at 07:30 am in fasted condition during one day)
- Body composition: lean mass(at 07:30 am during one day)
- cardiac output(at 11:30 am during one day)
- peripheral quantitative computed tomography(at 10:45 am during one day)
- physical condition(at 08:45 am during one day)