Reversal through TRH of opioid-induced respiratory depression (OIRD) in healthy volunteers

Completed

• Conditions: opiaat-geinduceerde ademdepressie; opioid-induced respiratory depression

• Registration Number: NL-OMON46759
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Trial ended prematurely

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-08-23
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 7

Inclusion Criteria

- Healthy male or female volunteers;
- Age: 18 - 40 years;
- Body mass index < 30 kg/m2;
- Able to give informed consent.

Exclusion Criteria

- Known or suspected neuromuscular or a (family) history of any
neuromuscular disease;
- A history of allergic reaction to food or medication including study
medication;
- Any current or previous medical (including high blood pressure),
neurological or psychiatric illness (including a history of anxiety);
- Alcohol abuse (> 21 units/week);
- Illicit drug use in the past 30 days before inclusion;
- Pregnancy or lactation;
- Participation in any medical or drug trial in the month prior to the
current study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Ventilation</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>