Efficacy of Dexamethasone in Treatment of Meconium Aspiration Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- The number of days required for ventilation in participants
研究概览
简要总结
Objective: To determine efficacy of dexamethasone in treatment of meconium aspiration syndrome.
Study design: Randomized control trial. Place and duration: Services hospital, Neonatal unit, Lahore. During time span of 1st January to 30th June 2021.
Material and methods Total 100 neonates were randomly divided in two groups. Group A (n=50) was treated with dexamethasone (Cases) and Group B (n=50) served as control. Dexamethasone was given in dose of 0.2mg/kg, 12 hourly for 7 days after confirmation of diagnosis. Infants present in clinical trial were evaluated by ventilation duration (invasive and non-invasive), oxygen therapy and hospital stay.
详细描述
Data was analyzed in statistical analysis SPSS version 23. Means and Standard deviation were calculated for duration of non-invasive and invasive ventilation, hospital stay and oxygen therapy. Independent sample T test was applied and value < 0.05 was taken as significant. Whereas frequency and percentages were taken for gender, gestation, mode of delivery and outcome of MAS and Chi-square test was applied, and p value < 0.05 was taken as significant.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- — 至 24 Hours（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Term and Post-Term babies who met the operational definition of MAS (inborn)
- •Presenting within 24 hours of life
排除标准
- •Preterm babies or babies with congenital malformations
- •Preterm babies or babies with dysmorphism
- •Preterm babies or babies with hypoxic-ischemic encephalopathy
研究组 & 干预措施
Group A (Dexamethasone Group),
Group A (Case Group) was given dexamethasone i.e., 0.2 mg per kg per day every 12 hours for 7 days intravenously. All treatment strategies were same in both groups but steroid was given to group A
干预措施: Dexamethasone (Drug)
结局指标
主要结局
The number of days required for ventilation in participants
时间窗: 7 days
The purpose of study was to measure number of days required for ventilation in participants
The number of days required for oxygen therapy in participants
时间窗: 7 days
The purpose of study was to measure number of days required for oxygen therapy in participants
The number of days required for hospitalization in participants
时间窗: 7 days
The purpose of study was to measure number of days required for hospitalization in participants
次要结局
未报告次要终点