Assessment on the effect of Melatonin on Pain control after Abdominal Hystrectomy
Phase 2
- Conditions
- Pain after abdominal hystrectomy.Postprocedural disorder of genitourinary system, unspecified
- Registration Number
- IRCT2015090816325N3
- Lead Sponsor
- Vice Chancellor for Research-Guilan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 60
Inclusion Criteria
Inclusion Criteria:Totalm Abdominal Hystrectomy; Age 35-55; ASA I,II
Exclusion criteria: Patients in consider to Cardial; Pulmonary; hepatic; Renal; autoimmune; pscychologic; gastrointestinal diseases; Diabetis; sleep disorders; Epilepsia; Nystagmous; Leukemia; speech and hearing disorders; seasonal and drug allergies; chronic analgesia; hypnotics; pscychotropic; opioid; Beta blockers and MAOI consumption; adverse drug reactions; patients refuse to collaboration.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pregabalin(50 mg) with a glass of water. Timepoint: Two hours before the surgery. Method of measurement: mg/kg.;Melatonin. Timepoint: Two hours before the surgery. Method of measurement: Mg/kg.;Fentanyl. Timepoint: Hours(1-6-12-24). Method of measurement: µg/kg.
- Secondary Outcome Measures
Name Time Method Intense of pain. Timepoint: During first hour after the. Method of measurement: surgery.;Serum Melatonin. Timepoint: During first hour after the surgery. Method of measurement: pg/mL.;Serum Beta Endorphin. Timepoint: During first hour after the surgery. Method of measurement: ng/L.