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临床试验/CTRI/2025/01/079559
CTRI/2025/01/079559尚未招募2 期

Evaluating the Effect of Ujjayi pranayama on heart rate variability in Hypertension-A Randomised controlled trial

Dr Pavithra S1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2025年2月10日最近更新:

试验速览

阶段
2 期
状态
尚未招募
发起方
入组人数
80
试验地点
1
主要终点
Heart rate variability

研究概览

简要总结

Hypertension (HTN) is defined by a systolic blood pressure (SBP) of 130 mm Hg or higher and/or a diastolic blood pressure (DBP) of 80 mm Hg or higher. It is one of the most prevalent chronic conditions and a leading cause of stroke, heart disease, heart failure, and kidney failure. In India, hypertension is responsible for a significant percentage of fatalities. One reason for this is a lack of awareness, as many individuals remain asymptomatic until major health issues arise. Around 90-95% of hypertension cases are primary (essential), caused by environmental, genetic, and lifestyle factors such as poor diet, smoking, alcohol, and sedentary habits. Age-related metabolic disorders like insulin resistance also contribute to higher blood pressure, which increases the risk of various cardiovascular and kidney diseases. Management of hypertension involves lifestyle changes like diet and exercise. If ineffective, medication such as diuretics, beta-blockers, calcium channel blockers, ACE inhibitors, and ARBs may be prescribed to achieve a target blood pressure of 130/80 mm Hg or lower. Yoga, especially pranayama (breathing exercises), has been found to have a significant antihypertensive effect. Pranayama involves controlled breathing techniques like inhalation, retention, and exhalation to regulate heart rate and blood pressure. It reduces heart rate and both systolic and diastolic blood pressure, benefiting the cardiovascular system. Ujjayi pranayama, known as "victorious breath," is particularly beneficial for reducing stress and improving cardiovascular function. This technique helps restore autonomic balance by reducing sympathetic nervous activity and enhancing parasympathetic response, which improves heart rate and overall heart health. Heart rate variability (HRV) is a useful tool to assess autonomic nervous system function, and studies show that pranayama can increase HRV, improving the balance between the sympathetic and parasympathetic systems. This balance is essential for managing stress and hypertension effectively. Overall, yoga and pranayama provide a complementary approach to hypertension management by promoting relaxation, improving autonomic function, and reducing stress. These practices offer an additional, natural option for those seeking non-pharmacological ways to manage their blood pressure.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
30.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • Patients under a single drug or two drug combination.
  • Moderate hypertensive (systolic 140–179 mmHg) and (diastolic 90–109 mmHg) (2017 American Heart Association (AHA)guidelines).

排除标准

  • Patients with secondary hypertension
  • Diabetes mellitus, coronary artery dis-ease, heart failure, arrhythmia, rheumatic heart disease, congenital heart disease, and other significant systemic (renal, hepatic, pulmonary, neurological and psychiatric) diseases or complications.
  • Those who are practicing yoga regularly for more than one or three months.
  • Women during pregnancy and menstruation.
  • Hypertensive patients with Blood Pressure beyond Moderate hypertension (2017 AHA guidelines).

结局指标

主要结局

Heart rate variability

时间窗: Before and after completing the intervention for a period of 14 days

次要结局

  • blood pressure(Before and after completing the intervention for a period of 14 days)

研究者

发起方
Dr Pavithra S
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Dr Pavithra S

International institute of yoga and naturopathy medical sciences

研究点 (1)

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