Effects of Cocoa Flavanol on Skin Aging

Not Applicable

Completed

• Conditions: Photo-aging; Ageing
• Interventions: Dietary Supplement: Cocoa flavanol beverage; Dietary Supplement: Placebo beverage

• Registration Number: NCT02060097
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) likely contribute to this process. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined.

Cocoa beans fresh from the tree are exceptionally rich in polyphenols, such as flavanol, and have a higher antioxidant capacity. The present study is designed to investigate the effects of long-term intake of a product rich in cocoa flavanols on facial wrinkles, hydration, elasticity and photosensitivity.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-02
• Study First Submitted: 2014-02-09
• Study First Submitted QC: 2014-02-09
• Study First Posted: 2014-02-11
• Primary Completion: 2015-03
• Study Completion: 2015-03
• Status Verified: 2016-06
• Last Update Submitted: 2016-06-11
• Last Update Posted: 2016-06-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 64

Inclusion Criteria

• Healthy females aged ≥ 40 years
• Facial wrinkle grade ≥ 2

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Exclusion Criteria

• received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study
• reported taking functional foods 1 month before the study
• history of acute or chronic disease such as severe liver or kidney disease or uncontrolled diabetes
• history of allergies against any component of trial foods
• any visible skin disease that might be confused with a skin reaction to the test procedure

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cocoa flavanol beverage	Cocoa flavanol beverage	flavanol 320mg/day
Placebo beverage	Placebo beverage	no flavanol

Primary Outcome Measures

Name	Time	Method
Change from baseline in skin wrinkles at week 24	baseline, week 24	Facial wrinkles in the crow's feet area measured as R1-3

Secondary Outcome Measures

Name	Time	Method
Change from baseline in skin hydration at week 12	baseline, week 12	Skin hydration measured by Corneometer
Change from baseline in skin elasticity at week 24	baseline, week 24	Facial elasticity measured as R2, R5, R7
Change from baseline in minimal erythema dose at week 24	baseline, week 24
Change from baseline in skin color at week 12	baseline, week 12	Skin color measured as erythema index and melanin index

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of