Effects of 24-week Cocoa Flavanol Supplementation on Photo-aged Facial Skin
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 2
- 主要终点
- Change from baseline in skin wrinkles at week 24
研究概览
简要总结
Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) likely contribute to this process. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined.
Cocoa beans fresh from the tree are exceptionally rich in polyphenols, such as flavanol, and have a higher antioxidant capacity. The present study is designed to investigate the effects of long-term intake of a product rich in cocoa flavanols on facial wrinkles, hydration, elasticity and photosensitivity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy females aged ≥ 40 years
- •Facial wrinkle grade ≥ 2
排除标准
- •received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study
- •reported taking functional foods 1 month before the study
- •history of acute or chronic disease such as severe liver or kidney disease or uncontrolled diabetes
- •history of allergies against any component of trial foods
- •any visible skin disease that might be confused with a skin reaction to the test procedure
结局指标
主要结局
Change from baseline in skin wrinkles at week 24
时间窗: baseline, week 24
Facial wrinkles in the crow's feet area measured as R1-3
次要结局
- Change from baseline in skin hydration at week 12(baseline, week 12)
- Change from baseline in skin elasticity at week 24(baseline, week 24)
- Change from baseline in minimal erythema dose at week 24(baseline, week 24)
- Change from baseline in skin color at week 12(baseline, week 12)
研究者
Jin Ho Chung
Professor
Seoul National University Hospital