Flavanols and Skin Photo Protection: a Double Blind Clinical Trial

Laval University1 site in 1 country78 target enrollmentJune 2011

ConditionsSolar Skin Damage

Overview

Phase: Phase 2
Intervention: Not specified
Conditions: Solar Skin Damage
Sponsor: Laval University
Enrollment: 78
Locations: 1
Primary Endpoint: Change in Minimal erythema dose
Status: Completed
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

As flavanols have antioxidants, anti-inflammatory and anti-DNA damaging effects and may increase microcirculation in skin, the purpose of the study is to investigate the chronic effect of flavanol-rich chocolate as an effective strategy to protect against the harmful effect of ultraviolet (UV) radiation.

Detailed Description

Recent data suggested that chronic ingestion of high flavanols cocoa might be a promising agent for dietary photo protection against UV light. Moreover, flavanols-rich cocoa intake has been shown to increase microcirculation in human skin.

Registry

clinicaltrials.gov

Start Date

June 2011

End Date

May 2013

Last Updated

12 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Female

Investigators

Sponsor

Laval University

Responsible Party

Principal Investigator

Claudine Blanchet

Coordinator

Laval University

Eligibility Criteria

Inclusion Criteria

•Non-smoking women between the ages of 20 and 65 years.
•Normal skin of type I and II as decried by Fitzpatrick classification.

Exclusion Criteria

•Pregnancy and breast feeding.
•Photo sensibility: history of skin cancers, photosensitizing medication.
•Sun bed use or sunbathing in the previous 3 months.
•Use of supplements or natural health products (fish oils, coenzyme Q10, garlic, lycopene, beta carotene).
•Allergy or intolerance to nuts or chocolate.

Outcomes

Primary Outcomes

Change in Minimal erythema dose

Time Frame: within the first 12 weeks of chocolate intake and 3 weeks later after end of chocolate consumption

Secondary Outcomes

Change in Skin elasticity(within the first 12 weeks of chocolate intake and 3 weeks later after end of chocolate consumption)
Change in Skin moisture(within the first 12 weeks of chocolate intake and 3 weeks later after end of chocolate consumption)
Change in levels of Vitamin D and polyphenols(within the first 12 weeks of chocolate intake and 3 weeks later after end of chocolate consumption)