Wheat oral desensitization in patient with wheat allergy

Not Applicable

• Conditions: Condition 1: wheat allergy. Condition 2: Desensitization.; Adverse effects, not elsewhere classified; Desensitization to allergens

• Registration Number: IRCT201204199510N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

patients above 5 years with IgE mediated wheat allergy (positive skin prick test response to wheat flour and wheat specific IgE level above 0.35 IU/L); positive oral food challenge to wheat.
exclusion criteria: severe and uncontrolled asthma; chronic urticaria; significant systemic disease; poor compliance

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Daily consumption of wheat products without any complications. Timepoint: Before oral immunotherapy and 3 month after starting maintenance phase. Method of measurement: Oral food challenge with 52 gr of bread containing 5.2 g wheat protein.

Secondary Outcome Measures

Name	Time	Method
Evaluation of skin, respiratory, gastrointestinal symptoms and anaphylaxis reaction during course of treatment. Timepoint: During buildup and maintenance phase. Method of measurement: Number of participants with adverse events and observation of their sign and symptoms.