Clinical implications of asymptomatic corneal shedding of herpes simplex virus

Recruiting

• Conditions: herpetic keratitis; 10015919

• Registration Number: NL-OMON48221
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

- Age * 18 years.
- Informed consent.
- Immunecompetent individual.
- Positive HSV-1 infection status
- No symptomatic ocular HSV-1 disease during 3 months preceding first study
sampling.
- No anti-HSV therapy during 1 month preceding first study sampling.
- No immunesuppressive drugs during the 3 months preceding first study sampling.
- No previous keratoplasty

Exclusion Criteria

- Individual not able to adhere to bi-daily oral and corneal sampling for 30
consecutive days.
- Individuals wearing contact lenses

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters/endpoints: Proportion of HSV-1 DNA positive oral and<br /><br>corneal samples.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>