Accuracy of Methemoglobin Measurement for Rainbow Universal Pulse Oximeter Sensor
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 4
- 主要终点
- Accuracy of Sensor by Arms Calculation
研究概览
简要总结
In this study, the level of methemoglobin (HbMet) will be increased in a controlled manner by administering sodium nitrite intravenously in healthy volunteers. The accuracy of a noninvasive HbMet sensor will be assessed by comparison to blood measurements from a laboratory analyzer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •The subject is obese (BMI>30).
- •The subject has a known history of heart disease, lung disease, kidney or liver disease.
- •Diagnosis of asthma, sleep apnea, or use of CPAP.
- •Subject has diabetes.
- •Subject has a clotting disorder.
- •The subject has a hemoglobinopathy or history of anemia, per subject report or the first blood sample, that in the opinion of the investigator, would make them unsuitable for study participation.
- •The subject has any other serious systemic illness.
- •The subject is a current smoker.
- •Any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators' would interfere with the sensors working correctly.
- •The subject has a history of fainting or vasovagal response.
- •The subject has a history of sensitivity to local anesthesia or allergy to the study drugs.
- •The subject has a diagnosis of Raynaud's disease.
- •The subject has unacceptable collateral circulation based on exam by the investigator (Allen's test).
- •The subject is pregnant, lactating or trying to get pregnant.
- •The subject has a history of migraine headaches.
- •The subject is currently taking antidepressants.
- •The subject is unable or unwilling to provide informed consent, or is unable or unwilling to comply with study procedures.
- •The subject has any other condition, which in the opinion of the investigators' would make them unsuitable for the study.
研究组 & 干预措施
Rainbow Universal Pulse Oximeter Sensor
All subjects will be enrolled in the test group and will receive Rainbow Universal Pulse Oximeter Sensor.
干预措施: Rainbow Universal Pulse Oximeter Sensor (Device)
结局指标
主要结局
Accuracy of Sensor by Arms Calculation
时间窗: 5 hours
Accuracy willl be determined by comparing the noninvasive blood methemoglobin measurement (expressed as a percentage of total hemoglobin) of the pulse oximeter to that obtained from a blood sample and calculating the arithmetic root mean square(Arms) error value.
次要结局
未报告次要终点