Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries. A Randomized Clinical Trial
Trial Snapshot
- Phase
- Phase 4
- Status
- Recruiting
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Mean and Standard deviation of Blood loss (ml)(mean±SD)
Study Overview
Brief Summary
Objectives: To compare the safety and efficacy of oral atenolol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during nasal surgeries.
Background: Mucosal bleeding is the most frequent complication with nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, increases operation time, and consequently increases blood loss. There are several pharmacological and non-pharmacological techniques for the appropriate control of intraoperative bleeding.
Patients and Methods: This was a prospective, randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received oral atenolol, and group M, received oral metoprolol.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 21 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •American Society of Anesthesiologists (ASA) physical status ≤ II
- •Age from 21 to 50 years
Exclusion Criteria
- •ASA physical status > II
- •Age < 21 years or > 50 years
- •Pregnant women
- •Breastfeeding
- •Bronchial asthma
- •Chronic obstructive pulmonary disease
- •Diabetes Mellitus
- •Hypertension
- •Ischemic heart disease
- •Rheumatic heart disease
- •Heart failure
- •Heart block
- •Sick sinus syndrome
- •Sinus bradycardia
- •Chronic hypotension
- •Anemia (Hb < 10 g/dl)
- •Renal or hepatic dysfunction
- •Central nervous system disease
- •Allergic fungal sinusitis
- •Patients on beta-blockers
- •Alcohol or drug abuse
- •Anticoagulation therapy,
- •Bleeding diathesis
- •Agents influencing autonomic nervous system
- •Allergy to the study drugs
- •Any contraindication of oral intake
Arms & Interventions
Group A (n=30)
Atenolol group
Intervention: Atenolol Succinate Oral Tablet (Drug)
Group M (n=30)
Metoprolol group
Intervention: Metoprolol Succinate Oral Tablet (Drug)
Outcomes
Primary Outcomes
Mean and Standard deviation of Blood loss (ml)(mean±SD)
Time Frame: 5 minutes after the end of surgery
Amount of blood loss at the end of surgery
Secondary Outcomes
No secondary outcomes reported