Comparison Between Atenolol , Propnalol and Ivabradine as a Premedication for Bloodless Field Anesthesia in Lumbar Spine Surgery ,a Prospective Randomized Controlled Trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Menoufia University
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Perioperative Heamodynamic Effect of the drugs
Study Overview
Brief Summary
The aim of this work is to compare atenolol, propranolol, and ivabradine as a premedication to achieve bloodless field anesthesia primarily controlling heart rate in lumbar spine surgery.
Detailed Description
This study will investigate the effect of atenolol, propranolol, and ivabradine as oral premedication in adult patients undergoing LUMBAR SPINE SURGERY to achieve bloodless field anesthesia.
AIM OF THE WORK
- The primary aim of this work is to compare atenolol, propranolol, and ivabradine as a premedication to achieve bloodless field anesthesia primarily controlling heart rate in lumbar spine surgery.
- The secondary aims are to assess field visibility and measure the amount of blood loss in patients, and surgeon satisfaction and also to asses if there are any associated undesirable side effects of atenolol, propranolol, or Ivabradine will appear.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •ASA physical status I and II,
- •aged from 18 to 50 years old
- •scheduled for elective lumber spine surgeries will be included in this study.
Exclusion Criteria
- •Hypertension.
- •Hepatic or renal disease.
- •Diabetes Mellitus.
- •Pregnancy.
- •Coagulation disorders.
- •Anemia (Hb < 10 g/dL).
- •Ischemic heart disease
- •Drug or alcohol abuse.
- •Allergy to any of atenolol, propranolol, and ivabradine.
- •History of beta-blockers, calcium channel blockers, Tricyclic antidepressants, anticoagulant or clonidine intake.
Arms & Interventions
Atenolol Group
patients will be premedicated with atenolol (50mg)
Intervention: Atenolol 50 MG (Drug)
propranolol Group
patients will be premedicated with propranolol (10mg)
Intervention: Propranolol Pill (Drug)
Ivabradine Group
patients will be premedicated with Ivabradine (5mg)
Intervention: Ivabradine (Drug)
Outcomes
Primary Outcomes
Perioperative Heamodynamic Effect of the drugs
Time Frame: every 5 minutes for 15 minutes and then every 10 minutes till end of surgery, then every 15 minutes for 1hour in the recovery room
Heart rate
Secondary Outcomes
- Blood loss & surgical field visibility score(Intraoperative time)
- Anesthetic consumption(Intraoperative time)
- Incidence of complication(Intraoperative time)
- The need for blood transfusion(Intraoperative time)
Investigators
rabab Mohammad habeeb
Principal investigator
Menoufia University