Genetic and metabolic biomarkers for the recovery of circulatory function after heart surgery
Recruiting
- Conditions
- Major cardiac surgery for coronary heart disease and valve defects
- Registration Number
- DRKS00034339
- Lead Sponsor
- niversitätsmedizin Göttingen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
• Age over 18 years
• Capacity to consent before surgery
• Ability to receive information and give consent before surgery
• Open-heart surgery
• Surgeries with and without a heart-lung machine
Exclusion Criteria
• Condition after resuscitation
• Patients with end-stage renal failure (eGFR < 20 ml/min)
• Patients with severe heart failure (NYHA > 3 or EF < 25)
• Patients with liver cirrhosis (Child-Pugh groups B and C, typically significantly elevated serum bilirubin and prolonged INR)
• Patients with clinically relevant congenital heart defects
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Plasma concentration of biomarkers (carnitine derivatives, tryptophan derivatives, L-citrulline, L-arginine, and other metabolites from energy, protein, and fat metabolism) before, within the first 24 hours, and after 3 to 6 days following cardiac surgery.<br>2. Inherited genomic variants and non-genetic parameters (mRNA expression, DNA methylation in peripheral blood) of enzymes involved in catecholamine, lipid, and amino acid metabolism, and of transport proteins in the liver and kidney.
- Secondary Outcome Measures
Name Time Method 1. Catecholamine dosages intraoperatively and postoperatively<br>2. Return of spontaneous breathing and extubation time<br>3. Early postoperative organ dysfunction